Susan Shortreed, PhD

“By using rich data sources such as electronic health records, we can begin to identify which treatments will work best for which people.”

Susan M. Shortreed, PhD

Senior Biostatistics Investigator, Kaiser Permanente Washington Health Research Institute
Affiliate Professor, Department of Biostatistics, University of Washington

Susan.M.Shortreed@kp.org
206-287-2088

Curriculum vitae (CV)

Biography

Susan Shortreed, PhD, uses statistics and machine learning methods to address health science problems, with a special emphasis on analyzing complex longitudinal data. She develops and evaluates statistical approaches for observational data, and works to improve the design and analyses of studies that use data collected from electronic health care records. She is leading a project to develop statistical methods for constructing personalized treatment strategies using data captured from electronic health records.

Dr. Shortreed earned her PhD in statistics from the University of Washington. Then she spent two years in the Department of Epidemiology and Preventive Medicine at Monash University in Melbourne, Australia, and two years in the School of Computer Science at McGill University in Montreal, Canada. Dr. Shortreed has collaborated with scientists in a broad range of areas including alcohol use, cancer screening, and medication safety. She now works alongside researchers in mental and behavioral health, evaluating and comparing treatments for chronic pain and depression, and interventions to prevent suicide. Dr. Shortreed is an investigator with the Mental Health Research Network, designing studies to address important public health concerns, such as determining which antidepressant medications work best for which patients and developing risk prediction algorithms to identify individuals who may be at increased risk for suicidal behavior.

Dr. Shortreed is also an affiliate professor of biostatistics at the University of Washington School of Public Health. She served on the executive board for the American Statistical Association’s Section on Statistics in Epidemiology and the editorial board of the Journal of the Royal Statistical Society, Series C: Applied Statistics.

Research interests and experience

Biostatistics

Design and analysis of studies that use data collected from electronic health records; analysis of complex longitudinal data; methods for constructing personalized treatment strategies, computational statistics and algorithms; machine learning; variable selection methods.

Medication Use & Patient Safety

Biostatistics; machine learning; using data collected from electronic health records to study rare adverse events; opioid safety; medication safety in pregnancy.
Mental Health

Biostatistics; treatment for chronic depression; suicide prevention; developing personalized treatment strategies; developing risk prediction models.

Recent publications

Saunders K, Shortreed S, Thielke S, Turner JA, LeResche L, Beck R, Von Korff M. Evaluation of health plan interventions to influence chronic opioid therapy prescribing. Clin J Pain. 2015 Jan 23. PubMed

Friesen MC, Shortreed SM, Wheeler DC, Burstyn I, Vermeulen R, Pronk A, Colt JS, Baris D, Karagas MR, Schwenn M, Johnson A, Armenti KR, Silverman DT, Yu K. Using hierarchical cluster models to systematically identify groups of jobs with similar occupational questionnaire response patterns to assist rule-based expert exposure assessment in population-based studies. Ann Occup Hyg. 2015 May;59(4):455-66. doi: 10.1093/annhyg/meu101. Epub 2014 Dec 3. PubMed

Turner JA, Saunders K, Shortreed SM, LeResche L, Riddell K, Rapp SE, Von Korff M. Chronic opioid therapy urine drug testing in primary care: prevalence and predictors of aberrant results. J Gen Intern Med. 2014 Dec;29(12):1663-71. doi: 10.1007/s11606-014-3010-y. Epub 2014 Sep 13. PubMed

Shortreed SM, Laber E, Scott Stroup T, Pineau J, Murphy SA. A multiple imputation strategy for sequential multiple assignment randomized trials. Stat Med. 2014 Oct 30;33(24):4202-14. doi: 10.1002/sim.6223. Epub 2014 Jun 11. PubMed

Friesen MC, Locke SJ, Zaebst D, Viet S, Shortreed S, Chen YC, Koh DH, Pardo L, Schwartz KL, Davis FG, Stewart PA, Colt JS, Purdue MP. Using machine learning to efficiently use multiple experts to assign occupational lead exposure estimates in a case-control study. Occup Environ Med. 2014 Jun;71 Suppl 1:A25-6. doi: 10.1136/oemed-2014-102362.79. PubMed

Vitiello MV, McCurry SM, Shortreed SM, Baker LD, Rybarczyk BD, Keefe FJ, Von Korff M. Short-term improvement in insomnia symptoms predicts long-term improvements in sleep, pain, and fatigue in older adults with comorbid osteoarthritis and insomnia. Pain. 2014 Aug;155(8):1547-54. doi: 10.1016/j.pain.2014.04.032. Epub 2014 May 1. PubMed

McClure JB, Peterson D, Derry H, Riggs K, Saint-Johnson J, Nair V, An L, Shortreed SM. Exploring the "active ingredients" of an online smoking intervention: a randomized factorial trial. Nicotine Tob Res. 2014 Aug;16(8):1129-39. doi: 10.1093/ntr/ntu057. Epub 2014 Apr 11. PubMed

Thielke SM, Turner JA, Shortreed SM, Saunders K, LeResche L, Campbell CI, Weisner CC, Von Korff MV. Do patient-perceived pros and cons of opioids predict sustained higher-dose use? Clin J Pain. 2014 Feb;30(2):93-101. doi: 10.1097/AJP.0b013e31828e361b. Epub 2013 Mar 26. PubMed

Turner JA, Saunders K, Shortreed SM, Rapp SE, Thielke S, LeResche L, Riddell KM, Von Korff M. Chronic Opioid Therapy Risk Reduction Initiative: impact on urine drug testing rates and results. J Gen Intern Med. 2014 Feb;29(2):305-11. doi: 10.1007/s11606-013-2651-6. Epub 2013 Oct 19. PubMed

Von Korff M, Shortreed SM, Saunders KW, LeResche L, Berlin JA, Stang P, Turner JA. Comparison of back pain prognostic risk stratification item sets. J Pain.2014 Jan;15(1):81-9. doi: 10.1016/j.jpain.2013.09.013. Epub 2013 Oct 4. PubMed