Greg Simon, MD, MPH, is a psychiatrist and senior investigator well-known for his extensive research on practical approaches to improving mental health care. He seeks to develop and evaluate effective real-world strategies that support better mental health and wellness.  Current areas of emphasis include identifying and assessing suicide risk, improving care for treatment-resistant depression, and reducing racial and ethnic disparities in mental health care.

Dr. Simon leads the Mental Health Research Network (MHRN), a consortium of research centers affiliated with 13 large health systems across the United States, including Kaiser Permanente Washington. This network, originally funded through a cooperative agreement with the National Institute of Mental Health, aims to improve the efficiency, relevance, and impact of mental health clinical and health services research. The MHRN is exploring a broad range of issues—including suicide prevention, improving heart health in people with serious mental illness, using electronic medical records to improve follow-up care for depression, and understanding the causes of racial and ethnic disparities in mental health care.

Dr. Simon and his MHRN colleagues have conducted several large studies across MHRN health systems, including:

• A pragmatic trial in four health systems examining the effect of systematic outreach programs to prevent suicide attempt among people at high risk.
• Using electronic health records from seven health systems to develop and validate machine learning models to identify people at high risk of suicidal behavior.
• A pragmatic trial in two health systems evaluating electronic health record tools to reduce risk of cardiovascular disease in people with bipolar disorder and schizophrenia.
• A rigorous evaluation of Zero Suicide care improvement programs in six health systems
• Developing measures to assess quality of care for depression in two health systems.

Dr. Simon sits on the editorial board for the journal General Hospital Psychiatry, and co-chairs the National Academy of Medicine’s Forum on Drug Discovery, Development and Translation.. Dr. Simon has practiced adult psychiatry in Kaiser Permanente Washington's Mental Health and Wellness Service since 1990.  He is also a professor in the department of Health Systems Science at the Bernard J Tyson Kaiser Permanente School of Medicine and an adjunct  professor inPsychiatry and Behavioral Dciences at the University of Washington.​​​