Onchee Yu, MS

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"At KPWHRI, I apply statistical methods to studies ranging from women’s health to pharmacoepidemiology to vaccine safety and effectiveness, in an effort to improve health care for patients.”

Onchee Yu, MS

Principal Collaborative Biostatistician, Kaiser Permanente Washington Health Research Institute

Onchee.Yu@kp.org
206-287-2389

Biography

Onchee Yu, MS, is a biostatistician who has extensive experience in statistical applications to electronic health records (EHR) data, which she has contributed to studies related to women’s health, pharmacoepidemiology, and vaccine safety and effectiveness. Ms. Yu has been a key member of the immunization research program at Kaiser Permanente Washington Health Research Institute (KPWHRI) over 20 years. Her work focuses on applying statistical methods to evaluate vaccine effectiveness, side effects, and safety. In collaboration with KPWHRI biostatisticians Jennifer Nelson, PhD, and Andrea Cook, PhD, Ms. Yu developed and improved statistical methods for monitoring the safety of postmarketing vaccines in the Vaccine Safety Datalink project.

Much of Ms. Yu's recent research is in pharmacoepidemiology, which is studying how drugs are used in a population and their impact on public health. She is an expert in statistical analysis in a complex, clinically important area — determining if medicine for one condition (for example, cardiovascular medications) affects risk of other illnesses (for example, dementia).

Addiction is another scientific area that Ms. Yu is involved in. In particular, she is a biostatistician on the PROUD (PRimary care Opioid Use Disorders) trial, a pragmatic implementation trial conducted in 6 diverse health systems to evaluate a program for increasing medication treatment for opioid use disorders within primary care settings.

Ms. Yu is also heavily involved in aging and geriatric research including collaborations with scientists on the Adult Changes in Thought (ACT) Study, a long-standing and ongoing longitudinal cohort study exploring risk factors related to dementia, Alzheimer's disease, and healthy aging. 

Ms. Yu obtained her master’s degree in biostatistics from the University of Washington in 1999. She also has prior experience and contribution to research in cancer and women’s health.

Research interests and experience

  • Biostatistics

    Survival analysis; classification and regression tree analysis

  • Cancer

    Biostatistics; medication use and cancer outcomes

  • Vaccines & Infectious Diseases

    Biostatistics; vaccine safety and efficacy; postmarketing vaccine safety study design and analysis

    Women's Health

    Biostatistics; incidence and prevalence estimations; validation of diagnosis codes; automated case-finding algorithms

  • Medication Use & Patient Safety

    Biostatistics; medication use and cancer outcomes; postmarketing drug and vaccine safety study design and analysis; safety signal detection methods

Recent publications

Jackson ML, Neuzil KM, Thompson WW, Shay DK, Yu O, Hanson CA, Jackson LA. The burden of community-acquired pneumonia in seniors: results of a population-based study. Clin Infect Dis. 2004;39(11):1642-50. Epub 2004 Dec 1. PubMed

Jackson LA, Neuzil KM, Yu O, Benson P, Barlow WE, Adams AL, Hanson CA, Mahoney LD, Shay DK, Thompson WW. Effectiveness of pneumococcal polysaccharide vaccine in older adults.  N Engl J Med. 2003;348(18):1747-55. PubMed

Reisch LM, Fosse JS, Beverly K, Yu O, Barlow WE, Harris EL, Rolnick S, Barton MB, Geiger AM, Herrinton LJ, Greene SM, Fletcher SW, Elmore JG. Training, quality assurance, and assessment of medical record abstraction in a multisite study. Am J Epidemiol. 2003;157(6):546-51. PubMed

Reiber GE, Smith DG, Wallace C, Sullivan K, Hayes S, Vath C, Maciejewski ML, Yu O, Heagerty PJ, LeMaster J. Two types of therapeutic shoes were no better than usual footwear for preventing foot reulceration. J Bone Joint Surg Am. 2002;84-A(11):2107. PubMed

Jackson LA, Yu O, Heckbert SR, Psaty BM, Malais D, Barlow WE, Thompson WW. Influenza vaccination is not associated with a reduction in the risk of recurrent coronary events. Am J Epidemiol. 2002;156(7):634-40. PubMed

 

Research

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Increasing opioid use disorder treatment in primary care

A trial led by KPWHRI researchers found that adding nurse care managers helped more people get needed treatment.

Research

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New numbers could help diagnose and treat a common, complex condition

Researchers gain better understanding of polycystic ovary syndrome's impact in U.S.

aging & geriatrics

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Do drugs cause falls for adults with dementia?

Researchers find a relationship between prescribed central nervous system-active medications and increased risk of falling among older people with dementia.