Onchee Yu, MS, is a biostatistician who has extensive experience in statistical applications to electronic health records (EHR) data, which she has contributed to studies related to women’s health, pharmacoepidemiology, and vaccine safety and effectiveness. Ms. Yu has been a key member of the immunization research program at Kaiser Permanente Washington Health Research Institute (KPWHRI) over 20 years. Her work focuses on applying statistical methods to evaluate vaccine effectiveness, side effects, and safety. In collaboration with KPWHRI biostatisticians Jennifer Nelson, PhD, and Andrea Cook, PhD, Ms. Yu developed and improved statistical methods for monitoring the safety of postmarketing vaccines in the Vaccine Safety Datalink project.
Much of Ms. Yu's recent research is in pharmacoepidemiology, which is studying how drugs are used in a population and their impact on public health. She is an expert in statistical analysis in a complex, clinically important area — determining if medicine for one condition (for example, cardiovascular medications) affects risk of other illnesses (for example, dementia).
Addiction is another scientific area that Ms. Yu is involved in. In particular, she is a biostatistician on the PROUD (PRimary care Opioid Use Disorders) trial, a pragmatic implementation trial conducted in 6 diverse health systems to evaluate a program for increasing medication treatment for opioid use disorders within primary care settings.
Ms. Yu is also heavily involved in aging and geriatric research including collaborations with scientists on the Adult Changes in Thought (ACT) Study, a long-standing and ongoing longitudinal cohort study exploring risk factors related to dementia, Alzheimer's disease, and healthy aging.
Ms. Yu obtained her master’s degree in biostatistics from the University of Washington in 1999. She also has prior experience and contribution to research in cancer and women’s health.
Survival analysis; classification and regression tree analysis
Biostatistics; medication use and cancer outcomes
Biostatistics; vaccine safety and efficacy; postmarketing vaccine safety study design and analysis
Biostatistics; incidence and prevalence estimations; validation of diagnosis codes; automated case-finding algorithms
Biostatistics; medication use and cancer outcomes; postmarketing drug and vaccine safety study design and analysis; safety signal detection methods
Pocobelli G, Yu O, Fuller S, Fraser JR, Wartko PD, Chen L, Newton KM, Dimer J, McCulloch DK, Warwick S, Dublin S One-Step Approach to Identifying Gestational Diabetes Mellitus: Association With Perinatal Outcomes 2018 Oct;132(4):859-867. doi: 10.1097/AOG.0000000000002780. PubMed
Gray SL, Anderson ML, Hanlon JT, Dublin S, Walker RL, Hubbard RA, Yu O, Montine TJ, Crane PK, Sonnen JA, Keene CD, Larson EB. Exposure to strong anticholinergic medications and dementia-related neuropathology in a community-based autopsy cohort. J Alzheimers Dis. 2018;65(2):607-616. doi: 10.3233/JAD-171174. PubMed
Jackson ML, Yu O, Nelson JC, Nordin JD, Tartof SY, Klein NP, Donahue JG, Irving SA, Glanz JM, McNeil MM, Jackson LA Safety of repeated doses of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine in adults and adolescents 2018 Aug;27(8):921-925. doi: 10.1002/pds.4569. Epub 2018-06-03. PubMed
Gray SL, Walker RL, Dublin S, Yu O, Aiello Bowles EJ, Anderson ML, Crane PK, Larson EB Proton Pump Inhibitor Use and Dementia Risk: Prospective Population-Based Study 2018 Feb;66(2):247-253. doi: 10.1111/jgs.15073. Epub 2017-11-14. PubMed
Boudreau DM, Yu O, Balasubramanian A, Wirtz H, Grauer A, Crittenden DB, Scholes D A Survey of Women's Awareness of and Reasons for Lack of Postfracture Osteoporotic Care 2017 Aug;65(8):1829-1835. doi: 10.1111/jgs.14921. Epub 2017-04-19. PubMed
A trial led by KPWHRI researchers found that adding nurse care managers helped more people get needed treatment.
Researchers gain better understanding of polycystic ovary syndrome's impact in U.S.
Researchers find a relationship between prescribed central nervous system-active medications and increased risk of falling among older people with dementia.