Recent publications on Aging & Brain Health

Shadyab AH, Zhang B, LaCroix AZ, McEvoy LK Randomization to hormone therapy and changes in plasma biomarkers of Alzheimer's pathology: The women's health initiative memory study 2026 Apr;207:108873 doi:10.1016/j.maturitas.2026.108873. doi: 10.1016/j.maturitas.2026.108873. Epub 2026-02-11. PubMed

Gibson LL, Suemoto CK, Attems J, Abner EL, Corrada MM, Gomez-Isaza L, Grinberg LT, Kapasi A, Jicha GA, Kawas C, Keene CD, Kovacs GG, Latimer CS, Leite REP, Montine T, Myllykangas L, Neltner AM, Troncoso J, Walker KA, Walker R, Wang SJ, Aarsland D, Nelson PT The prevalence of Lewy body pathology across nine international community-based cohorts 2026 Mar 26 doi: 10.1093/brain/awag112. Epub 2026-03-26. PubMed

Hickman SE, Lum HD, Unroe KT Family Caregiver Perspectives on Advance Care Planning Discussions for Residents With Dementia Led by Trained Nursing Home Staff: Insights From the APPROACHES Project 2026 Mar 26;27(5):106154. doi: 10.1016/j.jamda.2026.106154. Epub 2026-03-26. PubMed

Shadyab AH, Zhang B, LaCroix AZ, Mielke MM, Resnick SM, Nguyen S, Ferrucci L, Libermann TA, Ngo L, Casanova R, Reiner AP, Li D, Nievergelt CM, Maihofer AX, Manson JE, McEvoy LK Plasma Phosphorylated Tau 217 and Incident Mild Cognitive Impairment and Dementia in Older Women 2026 Mar 2;9(3):e261295. doi: 10.1001/jamanetworkopen.2026.1295. Epub 2026-03-02. PubMed

Nguyen S, Lu AT, Horvath S, Espeland MA, Rapp SR, Maihofer AX, Nievergelt CM, LaCroix AZ, McEvoy LK, Resnick SM, Beckman K, Shadyab AH Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study 2026 Mar;25(3):e70424. doi: 10.1111/acel.70424. PubMed

Gray SL, Yu O, Gatto NM, Marcum ZA, Latimer CS, Postupna N, Su YR, Barthold D, van Dalen JW, Richard E, Keene CD, Shaw PA, McEvoy LK, Larson EB, Crane PK Angiotensin II-Stimulating Antihypertensive Medications and Dementia-Related Neuropathology 2026 Feb 2;9(2):e2559113. doi: 10.1001/jamanetworkopen.2025.59113. Epub 2026-02-02. PubMed

Tabata-Kelly M, Palazzo LG, Perloff J, Kiel L, Parchman M, Penfold RB Champion-Led Deprescribing for Persons with Dementia in Primary Care: A Qualitative Study in Accountable Care Organizations 2026 Feb 2 doi: 10.1007/s11606-026-10234-8. Epub 2026-02-02. PubMed

Herman PM, Mann S, DeBar LL, Avins AL, Justice M, Nielsen A, Pressman A, Stone KL, Wellman R, Cook AJ Cost-Effectiveness of Acupuncture Needling for Older Adults With Chronic Low Back Pain 2026 Feb;51(3):E65-E75. doi: 10.1097/BRS.0000000000005549. Epub 2025-10-29. PubMed

McEvoy LK, Zhang B, Nguyen S, Maihofer AX, Nievergelt CM, Casanova R, Horvath S, Lu AT, Davatzikos C, Erus G, Resnick SM, Espeland MA, Rapp SR, Beckman K, Ferrucci L, Lacroix AZ, Shadyab AH Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration 2026 Jan 26 doi: 10.64898/2026.01.23.26344650. Epub 2026-01-26. PubMed

Harrington LB, Tom SE, Krakauer C, Wartko PD, Chau K, Muiruri R, Micks E, McEvoy LK, LaCroix AZ, Miller EC Adverse Pregnancy Outcomes and Cognitive Change in Older Women 2026 Jan;35(1):31-40 doi:10.1177/15409996251383009. doi: 10.1177/15409996251383009. Epub 2025-09-29. PubMed

Zhang B, McEvoy LK, Nguyen S, Espeland MA, Rapp SR, Horvath S, Lu AT, LaCroix AZ, Nievergelt CM, Maihofer AX, Resnick SM, Mielke MM, Beckman K, Li D, Silver B, Manson JE, Ferrucci L, Shadyab AH Epigenetic clocks and longitudinal plasma biomarkers of Alzheimer's disease 2025 Dec;21(12):e70983. doi: 10.1002/alz.70983. PubMed

Florez-Acevedo S, Greenwood-Hickman MA, Zhu W, Cook AJ, Delaney K, Green BB, Arterburn DE, McClure JB, Rosenberg DE Exploratory Analysis of Mental Health and Quality of Life Outcomes in a Randomized Controlled Trial to Reduce Sitting Time in Older Adults With Obesity 2025 Nov 12 doi: 10.1123/japa.2024-0387. Epub 2025-11-12. PubMed

Godrich D, Pasteris J, Martin ER, Kunkle B, Naj AC, Hamilton K, Wang H, Lee WP, Dumitrescu L, Hohman TJ, Mayeux R, Larson EB, Crane PK, Keene CD, Latimer C, Mukherjee S, Kofler J, Kamboh MI, Bennett DA, Molina-Porcel L, Schellenberg G, Pericak-Vance MA, Cuccaro M, Scott WK, Rundek T, Kukull W, Montine T, Beecham GW, Alzheimer's Disease Genetics Consortium (ADGC) Genome-wide association studies of TDP-43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B 2025 Nov;21(11):e70760. doi: 10.1002/alz.70760. PubMed

Phelan EA, Balderson BH, Fujii MM, Graham VF, Theis MK, Gray SL Deprescribing Central Nervous System-Active Medications Among Community-Dwelling Older Adults with Dementia in Primary Care: A Feasibility Study 2025 Oct 22;22(11). doi: 10.3390/ijerph22111611. Epub 2025-10-22. PubMed

Levoy K, Torke AM, Longtin K, Matthias MS, Hickman SE. A pilot study of a primary palliative care communication intervention (precursor) to address supportive oncology needs for patients with incurable cancer and their caregivers in the outpatient oncology setting. Cancer Control. 2025 Jan-Dec;32:10732748251390952. doi: 10.1177/10732748251390952. Epub 2025 Oct 17. PubMed

Ferrante GR, Kahn J, McCurry SM, Vitiello MV, Von Korff M, de la Iglesia HO Lunar rhythmicity in the actigraphic sleep patterns of older adults with chronic pain and sleep disturbances is associated with the severity of their self-reported sleep disturbance 2025 Oct 13 doi: 10.1093/sleep/zsaf230. Epub 2025-08-11. PubMed

Doubleday A, Blanco M, Adar SD, Hajat A, Li G, Larson EB, Crane PK, Sheppard L Traffic-related air pollutant exposure and physical performance in the Adult Changes in Thought cohort 2025 Oct;204:109850. doi: 10.1016/j.envint.2025.109850. Epub 2025-10-10. PubMed

Nguyen S, Lu A, Horvath S, Espeland MA, Rapp SR, Maihofer AX, Nievergelt CM, LaCroix AZ, McEvoy LK, Resnick SM, Beckman K, Shadyab AH Epigenetic clocks of biological aging and risk of incident mild cognitive impairment and dementia: the Women's Health Initiative Memory Study 2025 Oct doi: 10.1101/2025.09.29.25336927. Epub 2025-10-01. PubMed

Lee CS, Su YR, Walker RL, Krakauer C, Blazes M, Johnson EA, Cronkite D, Bowers W, Hess C, Arterburn D, Agrón E, Chew EY, Crane PK A Novel AMD Severity Scoring System Leveraging the AREDS Studies and Routine Clinical Electronic Medical Records 2025 Oct;132(10):1076-1087. doi: 10.1016/j.ophtha.2025.04.026. Epub 2025-04-29. PubMed

Krueger E, Mosher CE, Lewson A, Hickman SE, Wu W, Prigerson HG. Cancer prognostic awareness: Relations to patient and caregiver quality of life and care preferences J Pain Symptom Manage. 2025 Sep;70(3):313-323.e3. doi: 10.1016/j.jpainsymman.2025.06.002. Epub 2025 Jun 10. PubMed