Maricela Cruz, PhD

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“Developing flexible yet pragmatic and robust statistical methodology that can accommodate the intricacies of real-world circumstances is paramount in addressing public health concerns.”

Maricela Cruz, PhD

Associate Biostatistics Investigator, Kaiser Permanente Washington Health Research Institute
Affiliate Assistant Professor of Biostatistics, University of Washington

Biography

Maricela Cruz, PhD, is a biostatistician passionate about conducting public health research with a specific focus on improving the health of disenfranchised communities.

Dr. Cruz’s research centers on developing flexible and robust statistical methods to evaluate health care interventions, particularly using electronic health records, to inform clinical and public health practices. She specializes in analytic methods for pre-post longitudinal correlated data, including interrupted time series (ITS), time series analysis, longitudinal data, change-point detection, and difference-in-differences. Dr. Cruz additionally has experience in developing and evaluating prediction models. The pre-post methods she develops allow health systems to evaluate interventions over time, while her prediction model work helps identify at-risk encounters — both are critical in shaping effective health practices.

Dr. Cruz has developed and evaluated several ITS models to estimate the impact of new nursing structures (and similar health care interventions) on patient experience outcomes in the presence of potentially lagged (or anticipatory) treatment effects. To communicate and encourage access to her methods in the broader public health community, Dr. Cruz co-created the Robust Interrupted Time Series toolbox (https://biostatistics-kaust.github.io/robust_time_series_toolbox/), a stand-alone, user-friendly application implementing the Robust Multiple ITS model that Dr. Cruz developed in 2019 for single and multiple ITS.

Dr. Cruz provides statistical and scientific leadership in collaborative public health and health care delivery projects aimed at improving health outcomes for disenfranchised communities. She collaborates on several projects aiming to improve care for people with a history of suicide ideation and on projects designing and evaluating health care interventions, such as value-based drug formularies and clinical decision support systems for at-risk encounters.

Dr. Cruz obtained her PhD in statistics from the University of California Irvine in 2019. She is an affiliate assistant professor in biostatistics at the University of Washington.

Recent Publications

Bobb JF, Mooney SJ, Cruz M, Vernez Moudon A, Drewnowski A, Arterburn D, Cook AJ Distributed lag models for retrospective cohort data with application to a study of built environment and body weight 2025 Jan 7;81(1). doi: 10.1093/biomtc/ujae166. PubMed

Bender M, Cruz M, Coppin JD, Williams M Examining the Relationship Between Differing Implementation Patterns of an Evidence-Informed Frontline Nursing Care Model and Implementation Success in a National-Level Study 2025 Jan;2025:9652060. doi: 10.1155/jonm/9652060. Epub 2025-10-28. PubMed

Wolock CJ, Williamson BD, Shortreed SM, Simon GE, Coleman KJ, Yeargans R, Ahmedani BK, Daida Y, Lynch FL, Rossom RC, Ziebell RA, Cruz M, Wellman RD, Coley RY Importance of variables from different time frames for predicting self-harm using health system data 2024 Dec;160:104750. doi: 10.1016/j.jbi.2024.104750. Epub 2024-11-16. PubMed

Angerhofer Richards J, Cruz M, Stewart C, Lee AK, Ryan TC, Ahmedani BK, Simon GE Effectiveness of Integrating Suicide Care in Primary Care : Secondary Analysis of a Stepped-Wedge, Cluster Randomized Implementation Trial 2024 Nov;177(11):1471-1481. doi: 10.7326/M24-0024. Epub 2024-10-01. PubMed

Wolock CJ, Williamson BD, Shortreed SM, Simon GE, Coleman KJ, Yeargans R, Ahmedani BK, Daida Y, Lynch FL, Rossom RC, Ziebell RA, Cruz M, Wellman RD, Coley RY Importance of variables from different time frames for predicting self-harm using health system data 2024 Sep 20 doi: 10.1101/2024.04.29.24306260. Epub 2024-09-20. PubMed

 

Research

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Suicide attempts decreased after adding suicide care to primary care

Safety planning and risk screening improved outcomes for adult patients.

Research

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Neighborhood density connected to changes in body mass index for children

Study uses geographic data to track change over time.

KPWHRI in the media

Addressing structural racism in clinical prediction models

How structural racism is impacting clinical prediction models

JSM TV, Aug. 6, 2024