Nicole Gatto is a principal collaborative scientist at Kaiser Permanente Washington Health Research Institute (KPWHRI), where she predominantly works on the Adult Changes in Thought (ACT) Study examining Alzheimer's disease and related dementias.
Nicole’s research aims to increase our understanding of chronic diseases including neurodegenerative disorders, cardiovascular disease, and cancers. She has studied a broad range of risk and preventive factors including environmental, occupational, lifestyle, physiological, and genetic factors. She has led several funded epidemiologic studies, effectively utilizing data from cross-sectional, case-control, cohort, and experimental studies and applying different analytical approaches in her research. Recently, Nicole completed an investigation in the Adventist Health Study-2 cohort on lifestyle factors in mild cognitive impairment. Additionally, she has experience leading 2 separate diagnostic validation studies of over 600 self-reported Parkinson’s disease cases in the California Teachers Study cohort.
Nicole earned her Master of Public Health from the Fielding School of Public Health at UCLA and her PhD in epidemiology from the Department of Preventive Medicine at the Keck School of Medicine of the University of Southern California. Subsequently, she completed a 3-year post-doctoral fellowship at UCLA in environmental neuroepidemiology as well as a 1-year internship in communicable disease control and prevention at the Los Angeles County Department of Public Health. She holds certifications in public health, SAS, geographical information science, and college teaching.
In 2009, Nicole co-founded the Milagro Allegro Community Garden, a vibrant and thriving community space that integrates urban farming, art, and education in the Highland Park neighborhood of Northeast Los Angeles. In 2010, inspired by Michelle Obama’s “Let’s Move” campaign, Nicole developed, with colleagues, LA Sprouts, a nutrition, cooking, and gardening intervention aimed at reducing the risk of childhood obesity in predominantly Latino elementary school-aged children. From 2012 to 2017, she led the evaluation of the Little Green Fingers project, which constructed 8 community gardens across Los Angeles County.
In 2014, Nicole was a recipient of the Governor’s Environmental and Economic Leadership Award, California’s highest environmental honor. In 2018, she was awarded a Fulbright Specialist grant to teach epidemiology to public health professionals at the National Center of Public Health in Ulaanbaatar, Mongolia. In 2020, Nicole was named a Fulbright Scholar and, during 2021, she taught and conducted research at the University of Iceland in Reykjavik. In 2022, she was awarded a second Fulbright Specialist grant to consult on research and teach environmental health and epidemiology at the University of Cartagena, Colombia.
Nicole has faculty appointments at the University of Southern California and Loma Linda University, among others. She is a member of several professional societies, including the American Public Health Association and the International Society of Environmental Epidemiology. She serves as a reviewer for prominent public health journals, including Environmental Health Perspectives, Journal of the Neurological Sciences, and Public Health Nutrition. She also serves as guest editor for the journals Vaccines and Brain Sciences.
Nicole is inspired by the work of Wangari Maathai, who founded the Green Belt movement in Kenya, and Alice Waters, who created the Edible Schoolyard in Berkeley, California.
Gabitto MI, Travaglini KJ, Rachleff VM, Kaplan ES, Long B, Ariza J, Ding Y, Mahoney JT, Dee N, Goldy J, Melief EJ, Agrawal A, Kana O, Zhen X, Barlow ST, Brouner K, Campos J, Campos J, Carr AJ, Casper T, Chakrabarty R, Clark M, Cool J, Dalley R, Darvas M, Ding SL, Dolbeare T, Egdorf T, Esposito L, Ferrer R, Fleckenstein LE, Gala R, Gary A, Gelfand E, Gloe J, Guilford N, Guzman J, Hirschstein D, Ho W, Hupp M, Jarsky T, Johansen N, Kalmbach BE, Keene LM, Khawand S, Kilgore MD, Kirkland A, Kunst M, Lee BR, Leytze M, Mac Donald CL, Malone J, Maltzer Z, Martin N, McCue R, McMillen D, Mena G, Meyerdierks E, Meyers KP, Mollenkopf T, Montine M, Nolan AL, Nyhus JK, Olsen PA, Pacleb M, Pagan CM, Peña N, Pham T, Pom CA, Postupna N, Rimorin C, Ruiz A, Saldi GA, Schantz AM, Shapovalova NV, Sorensen SA, Staats B, Sullivan M, Sunkin SM, Thompson C, Tieu M, Ting JT, Torkelson A, Tran T, Valera Cuevas NJ, Walling-Bell S, Wang MQ, Waters J, Wilson AM, Xiao M, Haynor D, Gatto NM, Jayadev S, Mufti S, Ng L, Mukherjee S, Crane PK, Latimer CS, Levi BP, Smith KA, Close JL, Miller JA, Hodge RD, Larson EB, Grabowski TJ, Hawrylycz M, Keene CD, Lein ES Integrated multimodal cell atlas of Alzheimer's disease 2024 Dec;27(12):2366-2383. doi: 10.1038/s41593-024-01774-5. Epub 2024-10-14. PubMed
Gatto NM, Renz A, Tom SE, Lyons M, Macuiba JA, Dodd TS, Lind BK, Gray SL, Meyers K, Larson EB, Nelson JC, McEvoy LK, Sankaran S, Key D, Litondo JA, Crane PK The Adult Changes in Thought (ACT) Medical Records Abstraction Project: A Resource for Research on Biological, Psychosocial and Behavioral Factors on the Aging Brain and Alzheimer's Disease and Related Dementias 2024 Oct 28;14(11). doi: 10.3390/brainsci14111075. Epub 2024-10-28. PubMed
Hawrylycz M, Kaplan ES, Travaglini KJ, Gabitto MI, Miller JA, Ng L, Close JL, Hodge RD, Long B, Mollenkopf T, Mufti S, Gatto NM, Larson EB, Crane PK, Grabowski TJ, Keene CD, Lein ES SEA-AD is a multimodal cellular atlas and resource for Alzheimer's disease 2024 Oct;4(10):1331-1334. doi: 10.1038/s43587-024-00719-8. PubMed
Gibbons LE, Mobley T, Mayeda ER, Lee CS, Gatto NM, LaCroix AZ, McEvoy LK, Crane PK, Hayes-Larson E How Generalizable Are Findings from a Community-Based Prospective Cohort Study? Extending Estimates from the Adult Changes in Thought Study to Its Source Population 2024 Jan;100(1):163-174. doi: 10.3233/JAD-240247. PubMed
Gabitto MI, Travaglini KJ, Rachleff VM, Kaplan ES, Long B, Ariza J, Ding Y, Mahoney JT, Dee N, Goldy J, Melief EJ, Brouner K, Campos J, Carr AJ, Casper T, Chakrabarty R, Clark M, Compos J, Cool J, Valera Cuevas NJ, Dalley R, Darvas M, Ding SL, Dolbeare T, Mac Donald CL, Egdorf T, Esposito L, Ferrer R, Gala R, Gary A, Gloe J, Guilford N, Guzman J, Ho W, Jarksy T, Johansen N, Kalmbach BE, Keene LM, Khawand S, Kilgore M, Kirkland A, Kunst M, Lee BR, Malone J, Maltzer Z, Martin N, McCue R, McMillen D, Meyerdierks E, Meyers KP, Mollenkopf T, Montine M, Nolan AL, Nyhus J, Olsen PA, Pacleb M, Pham T, Pom CA, Postupna N, Ruiz A, Schantz AM, Sorensen SA, Staats B, Sullivan M, Sunkin SM, Thompson C, Tieu M, Ting J, Torkelson A, Tran T, Wang MQ, Waters J, Wilson AM, Haynor D, Gatto N, Jayadev S, Mufti S, Ng L, Mukherjee S, Crane PK, Latimer CS, Levi BP, Smith K, Close JL, Miller JA, Hodge RD, Larson EB, Grabowski TJ, Hawrylycz M, Keene CD, Lein ES Integrated multimodal cell atlas of Alzheimer's disease 2023 May 23 doi: 10.21203/rs.3.rs-2921860/v1. Epub 2023-05-23. PubMed
This year’s symposium was a virtual event drawing over 130 attendees.
Taking more breaks from sitting could potentially lower the risk.
Mapping the disease at the cellular level identifies possible new treatment targets.
For over 30 years, the Adult Changes in Thought (ACT) Study has been advancing our understanding of cognition, aging, and better ways to delay and prevent Alzheimer’s disease and related dementias.