Noorie Hyun, PhD
“It is fascinating to create solid bridges between real-world data and scientific research for public health using statistical thinking and tools. It is the reason why I love my job as a biostatistician.”
Noorie Hyun, PhD
Associate Biostatistics Investigator, Kaiser Permanente Washington Health Research Institute
Affiliate Assistant Professor, Department of Biostatistics, University of Washington
Biography
Biostatistician Noorie Hyun, PhD, collaborates on projects across a range of research at Kaiser Permanente Washington Health Research Institute, including addiction disorder, pragmatic clinical trials, cervical cancer screening, and drug and vaccine safety and effectiveness. Her current research focuses on designing and incorporating validation data to improve the precision of error-prone data from electronic health records and surveys and developing risk prediction models for personalized disease screening triage.
Before joining KPWHRI, Dr. Hyun worked as an assistant professor in the Division of Biostatistics and the Center for Advancing Population Science at the Medical College of Wisconsin. She provided scientific leadership, from study designs for observational studies and clinical trials through statistical analysis. Dr. Hyun also collaborated with the Surveillance and Health Equity researchers in the American Cancer Society to evaluate risks for cancer survivors compared to the general population as health disparity research.
Dr. Hyun received post-doctoral fellowship training in the Division of Cancer Epidemiology and Genetics (DCEG) at the National Cancer Institute. She developed statistical risk prediction models to estimate cervical cancer prevalence and incidence while addressing complex data-driven issues in large electronic health record systems such as the Kaiser Permanente Northern California cervical cancer screening cohort. Dr. Hyun also developed effective group testing methods for estimating prevalences of categorical traits and estimating the kappa statistic for agreement between 2 ordinal outcomes for multi-stage cluster sample data. All the developed methods were motivated by data-driven problems arising from collaborations with the DCEG epidemiologists.
Dr. Hyun received her PhD degree in biostatistics from the University of North Carolina at Chapel Hill. Her dissertation work focused on flexible semiparametric models to account for the measurement error in longitudinal biomarker outcome measurements and skewed distribution with a thick tail for the biomarker outcome. In the models, properly fitting the tail part of the distribution corresponding to abnormal/extreme blood glucose values as a diabetes biomarker detects well the association between biomarker and patient risk factors.
Areas of research focus
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Biostatistics
Time-to-event data analysis, semiparametric nonlinear regression models, measurement error and validation data, and complex probability samples (i.e., non-simple random samples) in health science
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Medication Use & Patient Safety
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Addiction
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Vaccines & Infectious Diseases
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Cancer
Recent Publications
Lapham GT, Hyun N, Bobb JF, Wartko PD, Matthews AG, Yu O, McCormack J, Lee AK, Liu DS, Samet JH, Zare-Mehrjerdi M, Braciszewski JM, Murphy MT, Arnsten JH, Horigian V, Caldeiro RM, Addis M, Bradley KA. Nurse care management of opioid use disorder treatment after 3 years: A secondary analysis of the PROUD cluster randomized clinical trial. JAMA Netw Open. 2024 Nov 4;7(11):e2447447. doi: 10.1001/jamanetworkopen.2024.47447. PubMed
Lapham GT, Bobb JF, Luce C, Oliver MM, Hamilton LK, Hyun N, Hallgren KA, Matson TE. Prevalence of cannabis use disorder among primary care patients with varying frequency of past-year cannabis use. J Gen Intern Med. 2024 Oct 24. doi: 10.1007/s11606-024-09061-6. [Epub ahead of print]. PubMed
Bobb JF, Idu AE, Qiu H, Yu O, Boudreau DM, Wartko PD, Matthews AG, McCormack J, Lee AK, Campbell CI, Saxon AJ, Liu DS, Altschuler A, Samet JH, Northrup TF, Braciszewski JM, Murphy MT, Arnsten JH, Cunningham CO, Horigian VE, Szapocznik J, Glass JE, Caldeiro RM, Tsui JI, Burganowski RP, Weinstein ZM, Murphy SM, Hyun N, Bradley KA. Offering nurse care management for opioid use disorder in primary care: Impact on emergency and hospital utilization in a cluster-randomized implementation trial. Drug Alcohol Depend. 2024;261:111350. doi: 10.1016/j.drugalcdep.2024.111350. Epub 2024 Jun 10. PubMed
Holt JM, Cusatis R, Mortensen N, Wolfrath N, Hyun N, Winn AN, Brown SA, Somai MM, Crotty BH. Twenty-first century house calls: a survey of ambulatory care providers to inform organisational telehealth strategy. BMJ Health Care Inform. 2022 Dec;29(1):e100626. doi: 10.1136/bmjhci-2022-100626. PubMed
Wartko PD, Bobb JF, Boudreau DM, Matthews AG, McCormack J, Lee AK, Qiu H, Yu O, Hyun N, Idu AE, Campbell CI, Saxon AJ, Liu DS, Altschuler A, Samet JH, Labelle CT, Zare-Mehrjerdi M, Stotts AL, Braciszewski JM, Murphy MT, Dryden D, Arnsten JH, Cunningham CO, Horigian VE, Szapocznik J, Glass JE, Caldeiro RM, Phillips RC, Shea M, Bart G, Schwartz RP, McNeely J, Liebschutz JM, Tsui JI, Merrill JO, Lapham GT, Addis M, Bradley KA; PROUD Trial Collaborators; Ghiroli MM, Hamilton LK, Hu Y, LaHue JS, Loree AM, Murphy SM, Northrup TF, Shmueli-Blumberg D, Silva AJ, Weinstein ZM, Wong MT, Burganowski RP. Nurse care management for opioid use disorder treatment: The PROUD cluster randomized clinical trial. JAMA Intern Med. 2023 Oct 30:e235701. doi: 10.1001/jamainternmed.2023.5701. [Epub ahead of print]. PubMed
Research
Increasing opioid use disorder treatment in primary care
A trial led by KPWHRI researchers found that adding nurse care managers helped more people get needed treatment.
preventive care
Exploring at-home cervical cancer screening
Kaiser Permanente is at the forefront of research looking at using home tests for HPV, a leading cause of cervical cancer.
Vaccine safety
COVID-19 vaccines and serious reactions: 3 questions answered
Jen Nelson, PhD, talks about monitoring reactions to the mRNA vaccines.
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