Lisa A. Jackson, MD, MPH
“Kaiser Permanente Washington gives us nearly unlimited potential to address vaccine effectiveness and safety questions of national and international importance.”
Lisa A. Jackson, MD, MPH
Senior Investigator, Kaiser Permanente Washington Health Research Institute
Physician, Washington Permanente Medical Group, Internal Medicine
Biography
Lisa A. Jackson, MD, MPH, is an internist and infectious disease epidemiologist who has conducted clinical and epidemiologic studies of vaccine safety and efficacy since 1991.
Dr. Jackson is the principal investigator (PI) of KPWHRI’s Vaccine and Treatment Evaluation Unit — one of 10 network sites that the National Institutes of Health (NIH) sponsors. In this role, she leads the phase 1 clinical trial of the COVID-19 vaccine co-developed by Moderna and NIH. Launched in March 2020, this trial was the first in the world to begin testing a COVID-19 vaccine. She is also leading the phase 3 clinical trials of the COVID-19 vaccines developed by Moderna and NIH and by Janssen Pharmaceutical Companies, part of Johnson & Johnson, at KPWHRI.
Additionally, Dr. Jackson serves as KPWHRI’s principal investigator in the Vaccine Safety Datalink Project (VSDP). Sponsored by the Centers for Disease Control and Prevention (CDC), VSDP conducts ongoing research on the safety of licensed vaccines in routine use.
Dr. Jackson has written more than 200 peer-reviewed publications and 14 book chapters. She is a past member of the Food and Drug Administration’s Vaccines and Related Biological Products Advisory Committee and the National Vaccine Program Office’s National Vaccine Advisory Committee.
After receiving her medical degree from the University of Virginia School of Medicine, in Charlottesville, Dr. Jackson earned her Master of Public Health (MPH) degree at the University of Washington (UW) School of Public Health. She completed her internal medicine residency training at the UW School of Medicine and served as an epidemic intelligence officer and preventive medicine resident at the CDC.
Research interests and experience
Vaccines & Infectious Diseases
Vaccine safety; COVID-19 vaccine safety and effectiveness; influenza vaccine effectiveness in the elderly; methodologic issues in vaccine effectiveness evaluations; pneumococcal polysaccharide vaccine effectiveness; pneumococcal conjugate vaccine immunogenicity in the elderly; epidemiology of E. coli bacteremia; epidemiology of community-acquired pneumonia
Recent publications
Babu TM, Jackson LA, El Sahly HM Next-Generation SARS-CoV-2 Vaccine Formulations and Alternative Routes of Administration 2025 Feb 4;231(1):44-48. doi: 10.1093/infdis/jiae504. Epub 2024-10-16. PubMed
Naleway AL, Crane B, Irving SA, Daley MF, Dixon B, Donahue J, Fuller CC, Fuller S, Getahun D, Glenn S, Hambidge SJ, Jackson LA, Kharbanda EO, Klein NP, Schmidt T, Sznajder K, Weinfield NS, Williams JTB, Zerbo O Vaccination During Pregnancy in the Vaccine Safety Datalink, 2002-2022 2025 Feb;44(2S):S105-S107. doi: 10.1097/INF.0000000000004607. Epub 2025-02-14. PubMed
Zhang B, Fong Y, Dang L, Fintzi J, Chen S, Wang J, Rouphael NG, Branche AR, Diemert DJ, Falsey AR, Graciaa DS, Baden LR, Frey SE, Whitaker JA, Little SJ, Kamidani S, Walter EB, Novak RM, Rupp R, Jackson LA, Yu C, Magaret CA, Molitor C, Borate B, Busch S, Benkeser D, Netzl A, Smith DJ, Babu TM, Kottkamp AC, Luetkemeyer AF, Immergluck LC, Presti RM, Bäcker M, Winokur PL, Mahgoub SM, Goepfert PA, Fusco DN, Atmar RL, Posavad CM, Mu J, Makowski M, Makhene MK, Nayak SU, Roberts PC, Gilbert PB, Follmann D, Coronavirus Variant Immunologic Landscape Trial (COVAIL) Study Team Neutralizing antibody immune correlates in COVAIL trial recipients of an mRNA second COVID-19 vaccine boost 2025 Jan 17;16(1):759. doi: 10.1038/s41467-025-55931-w. Epub 2025-01-17. PubMed
Duncombe CJ, Hergott DEB, Staubus WJ, Balke-Buijs M, Kublin JG, Duffy PE, Healy SA, Talley AK, Jackson LA, Sauerwein RW, Roestenberg M, Murphy SC Sex-Based Differences to Plasmodium Infection in the Placebo Arms of Controlled Human Malaria Infection (CHMI) Trials in Malaria-Naïve Populations: A Pooled Analysis 2025 Jan 13; https://doi.org/10.2139/ssrn.508739. doi: 10.2139/ssrn.5087394. PubMed
Markowitz LE, Hopkins RH, Broder KR, Lee GM, Edwards KM, Daley MF, Jackson LA, Nelson JC, Riley LE, McNally VV, Schechter R, Whitley-Williams PN, Cunningham F, Clark M, Ryan M, Farizo KM, Wong HL, Kelman J, Beresnev T, Marshall V, Shay DK, Gee J, Woo J, McNeil MM, Su JR, Shimabukuro TT, Wharton M, Keipp Talbot H COVID-19 Vaccine Safety Technical (VaST) Work Group: Enhancing vaccine safety monitoring during the pandemic 2024 Sep 17;42 Suppl 3(Suppl 3):125549. doi: 10.1016/j.vaccine.2023.12.059. Epub 2024-02-09. PubMed
Boyce TG, McClure DL, Hanson KE, Daley MF, DeSilva MB, Irving SA, Jackson LA, Klein NP, Lewin B, Williams JTB, Duffy J, McNeil MM, Weintraub ES, Belongia EA Lack of Evidence for Vaccine-Associated Enhanced Disease From COVID-19 Vaccines Among Adults in the Vaccine Safety Datalink 2024 Aug;33(8):e5863. doi: 10.1002/pds.5863. PubMed
Kharbanda EO, DeSilva MB, Lipkind HS, Romitti PA, Zhu J, Vesco KK, Boyce TG, Daley MF, Fuller CC, Getahun D, Jackson LA, Williams JTB, Zerbo O, Weintraub ES, Vazquez-Benitez G COVID-19 Vaccination in the First Trimester and Major Structural Birth Defects Among Live Births 2024 Aug;178(8):823-829. doi: 10.1001/jamapediatrics.2024.1917. Epub 2024-07-01. PubMed
Hechter RC, Qian L, Liu IA, Sy LS, Ryan DS, Xu S, Williams JTB, Klein NP, Kaiser RM, Liles EG, Glanz JM, Jackson LA, Sundaram ME, Weintraub ES, Tseng HF COVID-19 Vaccination Coverage and Factors Associated With Vaccine Uptake Among People With HIV 2024 Jun 3;7(6):e2415220. doi: 10.1001/jamanetworkopen.2024.15220. Epub 2024-06-03. PubMed
Vesco KK, Denoble AE, Lipkind HS, Kharbanda EO, DeSilva MB, Daley MF, Getahun D, Zerbo O, Naleway AL, Jackson L, Williams JTB, Boyce TG, Fuller CC, Weintraub ES, Vazquez-Benitez G Obstetric Complications and Birth Outcomes After Antenatal Coronavirus Disease 2019 (COVID-19) Vaccination 2024 Jun;143(6):794-802. doi: 10.1097/AOG.0000000000005583. Epub 2024-04-17. PubMed
El Sahly HM, Yildirim I, Frey SE, Winokur P, Jackson LA, Bernstein DI, Creech CB, Chen WH, Rupp RE, Whitaker JA, Phadke V, Hoft DF, Ince D, Brady RC, Edwards KM, Ortiz JR, Berman MA, Weiss J, Wegel A, DMID 17-0090 Study Group Safety and Immunogenicity of a Delayed Heterologous Avian Influenza A(H7N9) Vaccine Boost Following Different Priming Regimens: A Randomized Clinical Trial 2024 Feb 14;229(2):327-340. doi: 10.1093/infdis/jiad276. Epub 2023-07-19. PubMed
News
Vaccine program recruiting volunteers in Seattle area
KPWHRI’s vaccine registry was the first to enroll participants in a clinical trial of a COVID-19 vaccine.
News
Clinical trial will evaluate mpox vaccine for adolescents
The NIH-sponsored trial will help inform decisions about vaccine approval for 12- to 17-year-olds.
Research
New study confirms safety of shingles vaccine
KPWHRI researchers analyzed data from more than 640,000 vaccine doses to understand risk of severe reactions.
Research
‘Fighting back’ against COVID-19: Remembering a historic trial
Lisa Jackson, MD, MPH, Kaiser Permanente Washington senior investigator, recounts the genesis of a groundbreaking vaccine.
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