Rod Walker, MS, has developed a diverse research portfolio during his 15+ years as a biostatistician at KPWHRI. He has supported research collaborations across a wide range of topic areas including women's health, cancer, aging and geriatrics, physical activity and sedentary behavior, pharmacoepidemiology, opioids, traumatic brain injury, COVID-19, and mental health. Activities during his tenure have included serving as an analyst for the Statistical Coordinating Center for the National Cancer Institute's Breast Cancer Surveillance Consortium; evaluating health system initiatives aimed at reducing risks associated with chronic opioid therapy prescribing; and examining associations between various medication classes and outcomes such as pneumonia, fall-related injury, and dementia. He has also partnered with researchers in the Mental Health Research Network to leverage electronic health record data for predicting risk of suicide attempt and suicide death. These efforts have expanded his knowledge in machine learning, risk prediction, health informatics, and the practical challenges of implementing predictive tools into clinical workflows.
Mr. Walker’s longest-running collaboration is with the Adult Changes in Thought (ACT) study, an ongoing longitudinal cohort study seeking to bolster knowledge of risk factors related to dementia, Alzheimer's disease, and healthy aging. As the ACT study and its related projects have grown, he has contributed to analyses examining how medication use, biomarkers, and other exposures relate to cognitive outcomes in older adults — and has extended this work to investigate associations with neuropathology among participants who provided brain donations. His tenure with ACT has afforded him the opportunity to participate in varied activities such as processing and analyzing physical activity and sedentary behavior data from actigraphy devices worn by study participants; supporting development of prediction models to identify unrecognized dementia by leveraging the unique data available through ACT; and exploring relationships between eye diseases and dementia in collaboration with the Eye ACT ancillary study. Mr. Walker currently serves as co-lead of the ACT Data Science and Informatics Core, helping guide data infrastructure development and coordinate data sharing activities. Continued collaboration with ACT investigators remains a highlight of his research career at KPWHRI, as the study provides rich opportunities to advance public health knowledge relevant to aging populations.
Survival and longitudinal data analysis; epidemiology; machine learning; two-phase sampling
Biostatistics; cognitive health and dementia; neuropathologic correlates of dementia; factors associated with healthy aging
Biostatistics; suicide risk prediction; interventions for risk reduction; machine learning and health informatics
Biostatistics; pharmacoepidemiology; medication safety in older adults; opioids and chronic pain
Marcum ZA, Walker RL, Jones BL, Ramaprasan A, Gray SL, Dublin S, Crane PK, Larson EB Patterns of antihypertensive and statin adherence prior to dementia: findings from the adult changes in thought study 2019 Feb 14;19(1):41. doi: 10.1186/s12877-019-1058-6. Epub 2019-02-14. PubMed
Von Korff M, Saunders K, Dublin S, Walker RL, Thakral M, Sherman KJ, Ludman EJ, Hansen RN, Parchman M, Shortreed SM Impact of Chronic Opioid Therapy Risk Reduction Initiatives on Opioid Overdose 2019 Jan;20(1):108-117. doi: 10.1016/j.jpain.2018.08.003. Epub 2018-09-03. PubMed
Dublin S, Walker RL, Shortreed SM, Ludman EJ, Sherman KJ, Hansen RN, Thakral M, Saunders K, Parchman ML, Von Korff M Impact of initiatives to reduce prescription opioid risks on medically attended injuries in people using chronic opioid therapy 2019 Jan;28(1):90-96. doi: 10.1002/pds.4678. Epub 2018-10-30. PubMed
Aiello Bowles EJ, Crane PK, Walker RL, Chubak J, LaCroix AZ, Anderson ML, Rosenberg D, Keene CD, Larson EB Cognitive Resilience to Alzheimer's Disease Pathology in the Human Brain 2019 Jan;68(3):1071-1083. doi: 10.3233/JAD-180942. PubMed
Thakral M, Walker RL, Saunders K, Shortreed SM, Dublin S, Parchman M, Hansen RN, Ludman E, Sherman KJ, Von Korff M Impact of Opioid Dose Reduction and Risk Mitigation Initiatives on Chronic Opioid Therapy Patients at Higher Risk for Opioid-Related Adverse Outcomes 2018 Dec;19(12):2450-2458. doi: 10.1093/pm/pnx293. PubMed
Oral contraceptives, hormone therapy not linked to more severe COVID outcomes.
Study suggests pathology of brain cell loss after traumatic head injury is distinct from Alzheimer’s disease.
Models that are easier to explain, use could have better uptake in health care settings.