Research on health informatics at Kaiser Permanente Washington focuses on developing and using health information technology (IT) to transform health care delivery. By testing new paradigms of care that provide more opportunities to engage patients, this research is supplying valuable evidence that is helping shape federal policy and guiding innovative redesign of health care.
“We’re working to understand how to make health IT practical so patients and care teams find it useful and engaging,” explained Kaiser Permanente Washington Health Research Institute (KPWHRI) Senior Investigator James Ralston, MD, MPH. “We want to find ways to use information technologies to support patients and providers together, both inside and outside the office.”
Integral to this support is designing technologies that are user-friendly and meet the needs of both patients and providers. By applying human-centered methods that focus on needs, use, and usability, KPWHRI researchers inform the design of health IT with direct participation from users.
Groundbreaking methodological work by KPWHRI health informatics researchers includes developing natural language processing (NLP) to analyze text such as notes and written reports in electronic health records (EHRs). Assistant Investigator David Carrell, PhD, leads in the area of using NLP and machine learning to identify patient phenotypes, or specific health characteristics such as possible heart disease, risk of opioid overdose, or suggestion of colon cancer. This information can assist researchers in studying how genetics and other factors influence disease.
Other examples of KPWHRI health informatics research include projects using EHRs and secure electronic communications such as:
Examples of KPWHRI research in mobile health (mHealth) and user-centered design include:
“Our studies on using health IT to improve care are showing that we can achieve better outcomes when we shift care from the doctor’s office to where people live: in their homes—and online,” said Senior Investigator Beverly B. Green, MD, MPH.
Schuttner L, Staloff J, Theis M, Ralston JD, Rosland AM, Nelson K, Coyle L, Hagan S, Schult T, Solt T, Ritchey K, Sayre G. Perceived connections between personal values and health in high-risk patients with multimorbidity: A qualitative study. J Gen Intern Med. 2025 Mar 4. doi: 10.1007/s11606-025-09448-z. Online ahead of print. PubMed
Garcia S, Mahmud A, Dumke K, Erkenbeck A, Chao C, Mun S, Brown M. Understanding, assessing, and improving social health resource referrals in healthcare organizations. Health Serv Res. 2025 Feb 26:e14466. doi: 10.1111/1475-6773.14466. Online ahead of print. PubMed
Wyss R, van der Laan M, Gruber S, Shi X, Lee H, Dutcher SK, Nelson JC, Toh S, Russo M, Wang SV, Desai RJ, Lin KJ. Note on targeted learning with an undersmoothed Lasso propensity score model for large-scale covariate adjustment in health care database studies. Am J Epidemiol. 2025 Feb 7:kwaf024. doi: 10.1093/aje/kwaf024. Online ahead of print. PubMed
Weberpals J, Shaw PA, Lin KJ, Wyss R, Plasek JM, Zhou L, Ngan K, DeRamus T, Raman SR, Hammill BG, Lee H, Toh S, Connolly JG, Dandreo KJ, Tian F, Liu W, Li J, Hernández-Muñoz JJ, Schneeweiss S, Desai RJ. High-dimensional multiple imputation (HDMI) for partially observed confounders including natural language processing-derived auxiliary covariates. Am J Epidemiol. 2025 Jan 22:kwaf017. doi: 10.1093/aje/kwaf017. [Epub ahead of print]. PubMed
Tiro JA, Lykken JM, Chen PM, Clark CR, Kobrin S, Chubak J, Feldman S, Werner C, Atlas SJ, Silver MI, Haas JS. Delivering guideline-concordant care for patients with high-risk HPV and normal cytologic findings. JAMA Netw Open. 2025;8(1):e2454969. doi: 10.1001/jamanetworkopen.2024.54969. PubMed
![]() James D. Ralston, MD, MPHSenior Investigator |
![]() Beverly B. Green, MD, MPHSenior Investigator |
![]() Katharine A. Bradley, MD, MPHSenior Investigator |
![]() Paula Lozano, MD, MPHSenior Investigator; Director, ACT Center |
![]() Yates Coley, PhDAssociate Biostatistics Investigator |
![]() Brian D. Williamson, PhDAssistant Biostatistics Investigator |
![]() Annie Hoopes, MD, MPHActing Assistant Investigator |
![]() Claire Allen, MPHManager, Collaborative Science |
![]() Annie Piccorelli, PhDSenior Collaborative Biostatistician |