Yates Coley, PhD, is a biostatistician whose research promotes predictive analytics and learning health systems as a way to improve value quality, and equity in health care delivery. Their statistical research focuses on developing clinical prediction models that are accurate, actionable, and fair. This work spans several statistical domains including repeated measurements, missing data, and machine learning.
Dr. Coley’s paper examining racial and ethnic inequity in two suicide prediction models was awarded Paper of the Year at the Healthcare Systems Research Network 2021 Annual Conference. The two models performed well for visits by patients who were White, Hispanic, and Asian but did not accurately identify high-risk visits for patients who were Black, American Indian, and Alaskan Native, likely due to persistent structural barriers limiting access to affordable, high-quality, and culturally competent mental health care. The study emphasized the importance of assessing performance within racial and ethnic subgroups of all prediction models before clinical implementation to ensure that prediction models ameliorate, rather than exacerbate, existing health disparities.
Dr. Coley is a recent graduate of the CATALyST K12 Washington Learning Health System Program funded by the Agency for Healthcare Research and Quality and the Patient-Centered Outcomes Research Institute. As part of their training in learning health system research, Dr. Coley studied current barriers to implementing evidence-based predictive analytics tools to help develop prediction tools that can be deployed and sustained in clinical care. Their research plan also focused on statistical methods to address racial bias in clinical prediction algorithms.
Before starting as an assistant investigator at Kaiser Permanente Washington Health Research Institute (KPWHRI) in 2016, Dr. Coley was a postdoctoral research fellow at Johns Hopkins Bloomberg School of Public Health. There, they worked with urologists to develop a prediction model that enables personalized management of low-risk prostate cancer.
Dr. Coley completed their PhD in biostatistics at the University of Washington. Their dissertation research proposed methods to improve effectiveness estimates in HIV prevention trials by accounting for unobserved variability in risk.
At KPWHRI, Dr. Coley collaborates on projects across a range of research areas including mental health, breast cancer imaging, aging, and health services. They also lead predictive analytics work and direct biostatistical support for KPWHRI’s Center for Accelerating Care Transformation.
Bayesian analysis, causal inference, data visualization, hierarchical models, longitudinal data analysis, missing data, prediction, survival analysis
Suicide risk, depression treatment, measurement-based care, antipsychotic use in adolescents
Biostatistics, prostate cancer, risk stratification, stakeholder engagement, surveillance
Biostatistics, data visualization, interactive decision-support tools, learning health systems, stakeholder engagement
Biostatistics, clinical decision-support, learning health systems, patient-centeredness, shared decision-making, stakeholder engagement
Shortreed SM, Walker RL, Johnson E, Wellman R, Cruz M, Ziebell R, Coley RY, Yaseen ZS, Dharmarajan S, Penfold RB, Ahmedani BK, Rossom RC, Beck A, Boggs JM, Simon GE. Complex modeling with detailed temporal predictors does not improve health records-based suicide risk prediction. NPJ Digit Med. 2023;6(1):47. doi: 10.1038/s41746-023-00772-4. PubMed
Coley RY, Liao Q, Simon N, Shortreed SM. Empirical evaluation of internal validation methods for prediction in large-scale clinical data with rare-event outcomes: A case study in suicide risk prediction. BMC Med Res Methodol. 2023 Feb 1;23(1):33. doi: 10.1186/s12874-023-01844-5. PubMed
Richards JE, Yarborough BJH, Holden E, Shulman L, Stumbo SP, Coley Y, Simon GE. Implementation of suicide risk estimation analytics to support mental health care for quality improvement. JAMA Netw Open. 2022 Dec 1;5(12):e2247195. doi: 10.1001/jamanetworkopen.2022.47195. PubMed
Coley RY, Duan KI, Hoopes AJ, Lapham GT, Liljenquist K, Marcotte LM, Ramirez M, Schuttner L. A call to integrate health equity into learning health system research training. Learn Health Syst. 2022 Jul 24;6(4):e10330. doi: 10.1002/lrh2.10330. eCollection 2022. PubMed
Coleman KJ, Wellman R, Fitzpatrick SL, Conroy MB, Hlavin C, Lewis KH, Coley RY, McTigue KM, Tobin JN, McBride CL, Desai JR, Clark JM, Toh S, Sturtevant JL, Horgan CE, Duke MC, Williams N, Anau J, Horberg MA, Michalsky MP, Cook AJ, Arterburn DE, Apovian CM. Comparative safety and effectiveness of Roux-en-Y gastric bypass and sleeve gastrectomy for weight loss and type 2 diabetes across race and ethnicity in the PCORnet bariatric study cohort. JAMA Surg. 2022 Oct 1;157(10):897-906. doi: 10.1001/jamasurg.2022.3714. PubMed
KPWHRI researchers are contributing to better mental health care for people nationwide.
Their work contributes to improved quality of care and better understanding of patients’ needs.
Models that are easier to explain, use could have better uptake in health care settings.
Medscape, Aug. 9, 2022