Grants Awarded 2021

A 5-year, $348,882 grant from the National Heart, Lung, and Blood Institute. Major goals: The Research Evaluation and Commercialization Hubs (REACH) will address known disparities in the prevalence and management of hypertension among racial and ethnic minorities and among individuals from lower socio-economic backgrounds by combining digital health training with an enhanced digital and home monitoring intervention. The Kaiser Permanente Washington Health Research Institute lead investigator is Beverly Green.

Services to Support Studies of the Risk of New Malignancies Following Breast Cancer: Tissue Retrieval for Contralateral Breast Cancer Cases

A 1-year, $149,993 grant from the National Cancer Institute. Major goals: To examine pathological characteristics and molecular features of the index and contralateral tumors in the Kaiser Breast Cancer Survivors’ Cohort at Kaiser Permanente Washington Health Research Institute. The Kaiser Permanente Washington Health Research Institute lead investigator is Diana Buist.

A 2-year, $32,800 grant from the National Cancer Institute. Major goals: The major goal of this project is to estimate lifetime breast cancer outcomes in adult women under different scenarios for breast cancer screening. We will explore differences in the balance of benefits and harms as well as the efficiency of screening strategies in key subgroups of the population. The Kaiser Permanente Washington Health Research Institute lead investigator is Ellen O'Meara.

Improving Diversity, Inclusion, and Retention in BackinAction/AcuOA (Acupuncture for Chronic Low Back Pain in Older Adults)

A 1-year, $535,854 grant from the National Center for Complementary and Integrative Health. Major goals: The major goal of this supplement is to provide both evidence-based recruitment tools and important information about the risk factors associated with loss to follow-up at the Institute for Family Health, a network of federally qualified health centers. This should improve recruitment and retention of a diverse group of patients in the parent project, a pragmatic clinical trial of acupuncture for older adults with chronic low back pain. The Kaiser Permanente Washington Health Research Institute lead investigator is Karen Sherman.

Phase 1 Trial of a Replicating mRNA Vaccine Against SARS-CoV-2

A 2-year, $1,531,542 grant from the National Institute of Allergy and Infectious Diseases. Major goals: To evaluate the safety and immunogenicity of a range of doses (1 mcg, 5 mcg, and 25 mcg) of a nanoparticle, carrier-formulated, self-replicating replicon RNA (repRNA) Sars-CoV-2 vaccine (HDT-301) targeting a variant spike protein in unvaccinated or previously vaccinated healthy adults and when given as a 1-dose or 2-dose schedule. The Kaiser Permanente Washington Health Research Institute lead investigator is Lisa Jackson.

Safe and Sound-TASIE (Trauma-Informed ACEs Screening and Intervention Evaluation) Project ECHO (Extension for Community Healthcare Outcomes)

A 3-year, $270,000 grant from the U.S. Health Resources and Services Administration. Major goals: To contribute to evaluation and learning related to the implementation of ACEs (adverse childhood experiences) screening in pediatric primary care settings. This 3-year demonstration project aims to develop a sustainable and spreadable model for ACEs screening in the pediatric medical home. The Kaiser Permanente Washington Health Research Institute lead investigator is Lisa Schafer.

A 2-year, $32,800 grant from the National Cancer Institute. Major goals: The major goal of this project is to estimate lifetime breast cancer outcomes in adult women under different scenarios for breast cancer screening. We will explore differences in the balance of benefits and harms and the efficiency of screening strategies in key subgroups of the population. The Kaiser Permanente Washington Health Research Institute lead investigator is Ellen O'Meara.

Improving Diversity, Inclusion, and Retention in BackinAction/AcuOA (Acupuncture for Chronic Low Back Pain in Older Adults)

A 1-year, $535,854 grant from the National Center for Complementary and Integrative Health. Major goals: The major goal of this supplement is to provide both evidence-based recruitment tools and important information about the risk factors associated with loss to follow-up at the Institute for Family Health, a network of federally qualified health centers. This should improve recruitment and retention of a diverse group of patients in the parent project, a pragmatic clinical trial of acupuncture for older adults with chronic low back pain. The Kaiser Permanente Washington Health Research Institute lead investigator is Karen Sherman.

Phase 1 Trial of a Replicating mRNA Vaccine Against SARS-CoV-2

A 2-year, $1,531,542 grant from the National Institute of Allergy and Infectious Diseases. Major goals: The major goal of this trial is to evaluate the safety and immunogenicity of a range of doses (1 mcg, 5 mcg, and 25 mcg) of a nanoparticle, carrier-formulated, self-replicating replicon RNA (repRNA) SARS-CoV-2 vaccine (HDT-301) targeting a variant spike protein in unvaccinated or previously vaccinated healthy adults and when given as a 1-dose or 2-dose schedule. The Kaiser Permanente Washington Health Research Institute lead investigator is Lisa Jackson.

Safe and Sound-TASIE (Trauma-Informed ACEs Screening and Intervention Evaluation) Project ECHO (Extension for Community Healthcare Outcomes)

A 3-year, $270,000 grant from the Health Resources and Services Administration. Major goals: The major goal of this project is to contribute to evaluation and learning related to the implementation of ACEs (adverse childhood experiences) screening in pediatric primary care settings. This 3-year demonstration project aims to develop a sustainable and spreadable model for ACEs screening in the pediatric medical home. The Kaiser Permanente Washington Health Research Institute lead investigator is Lisa Schafer.

The Kaiser Permanente Washington Health Research Institute lead investigator is Karen Wernli.

Evaluating Acceptance and Screening Yield for Early Colorectal Cancer Testing (EASY CRC)

A 2-year, $180,018 grant from the Garfield Memorial Fund. Major goals: Although colorectal cancer (CRC) screening has been recommended to begin at age 50 for average-risk individuals, the increasing CRC prevalence among younger adults and results from modeling studies have led to new recommendations to begin screening at age 45. The major goal of this project is to test fecal immunochemical test-based CRC screening outreach in a sample of 20,000 members aged 45 to 49 across 4 Kaiser Permanente regions to evaluate screening uptake and outcomes in these adults. The Kaiser Permanente Washington Health Research Institute lead investigator is Aruna Kamineni.

Evaluation of Kaiser Permanente Medical Legal Partnership

A 3-year, $222,083 grant from the Kaiser Permanente Community Benefit. Major goals: The Medical Legal Partnership (MLP) aims to integrate robust MLP programs into the Kaiser Permanente (KP) care delivery system and build capacity of the community-based legal aid ecosystem to provide housing-related legal solutions that tackle housing instability and eviction risk for KP members and the community. The National Center for Medical-Legal Partnerships (NCMLP) will take a phased approach to providing technical assistance to KP care teams alongside a cohort of community-based legal organizations. KP National Program Office has asked the Center for Community Health and Evaluation (CCHE) to develop an evaluation proposal for MLP. The goals for this evaluation are currently under development. Based on current measurement priorities, we expect to prioritize the following evaluation questions, which will be refined further through conversations with stakeholders:

1. What is the reach of the MLP program (e.g., referrals provided, legal needs met, unique individuals served)?
2. What are short-term outcomes for patients served by the MLP (e.g., housing stability, self-reported health status, and satisfaction with services received)?
3. To what extent did the MLP program build KP staff capacity, community-based organization staff capacity, and cross-sector collaboration to address community-level housing and legal barriers?
4. What facilitators, challenges, and lessons learned arose from implementation of MLP?

The Kaiser Permanente Washington Health Research Institute lead investigator is Natasha Arora.

Food and Drug Administration Sentinel Medical Code Mapping

A 3-year, $182,350 grant from the U.S. Food and Drug Administration. Major goals: To assess the potential of data-driven statistical methods for detecting and reducing coding differences between health care systems in Sentinel. Findings will inform development and deployment of methods and computational tools for transferring knowledge learned from one site to another and pave the way toward scalable and automated harmonization of electronic health records data.  The Kaiser Permanente Washington Health Research Institute lead investigator is David Carrell.

Opioid Taper Support Program

A 3-year, $1,379,693 grant from Lokahi. Major goals: Design and implement a program to accelerate opioid dose reductions at scale by proactively reaching out to high-risk Kaiser Permanente Washington members in internal and external delivery systems and offering care management as they undertake the process of tapering opioids. The project will also enhance resources available to providers. The Kaiser Permanente Washington Health Research Institute lead investigator is Paula Lozano.

Optimizing Evidence-Based Practice Implementation for Clinical Impact: the IMPACT Center

A 4-year, $6,057,875 grant from the National Institute of Mental Health. Major goals: The IMPACT Center aims to optimize implementation research and practice through the development of new methods and associated toolkits to improve clinical outcomes for youth with common mental health problems served in community settings. The IMPACT Center will accomplish this work and refine methods through 3 exploratory projects and pilot projects and through offering training to grow capacity. The Kaiser Permanente Washington Health Research Institute lead investigator is Cara Lewis.

Pediatric Respiratory Illness Measurement System (PRIMES) Implementation in Community Hospital Settings

A 5-year, $3,954,759 grant from the National Heart, Lung, and Blood Institute. Major goals: This study will convene quality-improvement teams in 6 geographically dispersed community hospitals to improve on asthma and bronchiolitis quality measures included in the Pediatric Respiratory Illness Measurement System-Short Version (PRIMES-SV) tool. If the PRIMES-SV quality measures are found to be responsive to implementation science-informed quality-improvement strategies, this study has the potential to provide critical information needed to improve community hospital-based respiratory illness care and outcomes for children nationally. The Kaiser Permanente Washington Health Research Institute lead investigator is Rita Mangione-Smith.

Sentinel Year 8 (OY2022) Infrastructure

A 1-year, $110,554 grant from the U.S. Food and Drug Administration. Major goals:

1. Maintain the ability to trace Patient IDs and Encounter IDs across multiple extract, transform, and load (ETL) processes.
2. Execute all distributed queries using Statistical Analysis System® (SAS®) in Batch mode using SAS 9.4, when possible, for efficiency and security purposes.
3. Ensure sufficient WORK data library space to respond to queries within timeline. The Sentinel Operations Center recommends up to 3 times the ETL size, dependent on data partner size and number of concurrent queries.

The Kaiser Permanente Washington Health Research Institute lead investigator is David Carrell.

Sentinel Year 8 (OY2022) Querying

A 1-year, $53,127 grant from the U.S. Food and Drug Administration. Major goals: The major goals of this project are to participate in routine querying involving the execution of standard modular programs, sometimes supplemented with minimal amounts of custom coding developed by the Sentinel Operations Center (SOC), against a data partner’s production Sentinel Distributed Database, i.e., last approved refresh or extract, transform, and load (ETL). As a data partner, we will receive query requests and be asked to opt in by executing the routine query and transmitting aggregated results back to the SOC. The Kaiser Permanente Washington Health Research Institute lead investigator is David Carrell.

Systematic Review to Assess the Comparative Clinical Effectiveness of Treatments for COVID-19

A 1-year, $57,000 grant from the Institute for Clinical and Economic Review. Major goals: To review the safety, effectiveness, and value of treatments for mild to moderate COVID infections.  The Kaiser Permanente Washington Health Research Institute lead investigator is Kai Yeung.

Understanding Practical Alcohol Measures in Primary Care to Prepare for Measurement-Based Care: Scaled Electronic Health Records Measures of Alcohol Use and DSM-5 Alcohol Use Disorder Symptoms

A 3-year, $855,279 grant from the National Institute of Alcohol Abuse and Alcoholism. Major goals: To leverage electronic health records (EHRs) to understand how measures of alcohol consumption and DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition) alcohol use disorder symptoms function in the context of real-world routine care, including by understanding how these measures function psychometrically overall and across demographic groups (age, sex, race, and ethnicity) and how they are associated with subsequent health outcomes obtained from EHRs. The Kaiser Permanente Washington Health Research Institute lead investigator is Katharine Bradley.

Telehealth: Assessing Services at Kaiser Permanente (TASK)

A 2-year, $127,119 grant from Kaiser Foundation Hospitals. Major goals: To assess the effectiveness of telehealth for mental health issues. The Kaiser Permanente Washington Health Research Institute lead investigator is Robert Penfold.

A 1-year, $300,000 grant from the California Health Care Foundation. Major goals: The overarching goal of this evaluation will be to understand the impact of Delta Center California (DCC) and learn from its implementation, focusing on the successes, challenges, and barriers in meeting the specific project goals; the effectiveness of having local work inform policy efforts (and vice versa); and the strategy of collective policy action at the center of DCC. The Kaiser Permanente Washington Health Research Institute lead investigator is Erin Hertel.

California Health Care Foundation Birth Equity Project

A 2-year, $151,871 grant from the California Health Care Foundation. Major goals: As a result of the Docent Health partnership with patient navigators supporting mothers receiving care at CommonSpirit Health, the major goal is to investigate the following questions:

1. Are mothers being equitably navigated to resources? 
2. What is the impact on short-term and longer-term outcomes for mothers and babies?
3. What is the tech engagement for BIPOC communities, and what are barriers and facilitators?

The Kaiser Permanente Washington Health Research Institute lead investigator is Maggie Jones.

Eat Right Now Diabetes Prevention Program Translation

A 1-year, $96,207 grant from ShareCare Inc. Major goals: To translate the Centers for Disease Control and Prevention’s PreventT2 Diabetes Prevention Program curriculum into the Sharecare Eat Right Now program. The Kaiser Permanente Washington Health Research Institute lead investigator is David Arterburn.

Engaging Staff to Improve COVID-19 Vaccination Rates at Long-Term Care Facilities (ENSPIRE)

A 4-year, $3,528,429 grant from the Patient-Centered Outcomes Research Institute. Major goals: The major goal of the project is to compare the effectiveness of 2 communication and engagement interventions to promote COVID-19 vaccination for long-term care facilities workers against enhanced usual care communication strategies in a 3-arm cluster-randomized trial. The primary outcome will be vaccination rates at the facility level.  Secondary outcomes will include vaccine hesitancy and knowledge. The Kaiser Permanente Washington Health Research Institute lead investigator is Clarissa Hsu.

Real World Endpoints: Improving Probabilistic Phenotyping of Incident Outcomes through Enhanced Ascertainment with Natural Language Processing

A 3-year, $39,162 grant from the Food and Drug Administration. Major goals: This project will advance several themes related to Sentinel’s computable phenotyping strategy for electronic health record (EHR) data, including focusing on phenotyping methods for identifying incident (versus prevalent) conditions, focusing on a health outcome of interest that relies predominantly on unstructured EHR data and for which a clearly defined reference standard is absent, the need for rapid (near-real-time) natural language processing, and the evaluation of the generalizability of EHR-based phenotyping to neuropsychiatric events. The Kaiser Permanente Washington Health Research Institute lead investigator is David Carrell.

University of Washington Sweetened Beverages Tax Evaluation

A 1-year, $30,000 grant from Public Health Seattle and King County. Major goals: Evaluation of the city of Seattle's sweetened beverage tax. The Kaiser Permanente Washington Health Research Institute lead investigator is David Arterburn.

A 2-year, $1,407,973 grant from the National Institute of Allergy and Infectious Diseases. Major goals: To design and conduct Division of Microbiology and Infectious Diseases (DMID) clinical trial protocol 21-0002. The Kaiser Permanente Washington Health Research Institute lead investigator is Lisa Jackson.

A Phase 1/2 Study of Delayed Heterologous SARSCoV-2 Vaccine Dosing (Boost) after Receipt of EUA Vaccines

A 1-year, $500,000 grant from the National Institute of Allergy and Infectious Diseases. Major goals: To design and conduct Division of Microbiology and Infectious Diseases (DMID) clinical trial protocol 21-0012.  The Kaiser Permanente Washington Health Research Institute lead investigator is Lisa Jackson.

A Phase 1, Open-Label, Dose-Ranging Study of the Safety and Immunogenicity of 2019-nCov Vaccine (mRNA-1273) in Healthy Adults

A 2-year, $415,583 grant from the National Institute of Allergy and Infectious Diseases. Major goals: To enroll an additional cohort in Division of Microbiology and Infectious Diseases (DMID) clinical trial protocol 20-0003. The Kaiser Permanente Washington Health Research Institute lead investigator is Lisa Jackson.

AltaMed - Colorectal Cancer Screening

A 1-year, $39,100 grant from AltaMed Health Services Corporation. Major goals: The major goals of this project are to determine:

1. Do fotonovelas and texting contribute to improving colorectal cancer (CRC) screening rates among nonadherent populations aged 50-75 at AltaMed?
2. Are there differences in impact by demographics, type of insurance, and other factors in level of engagement with texting, fotonovelas, patient navigators, and screening?
3. What are lessons about facilitators, challenges, barriers to CRC screening in these populations?

The Kaiser Permanente Washington Health Research Institute lead investigator is Elena Kuo.

Kaiser Washington Vaccine and Treatment Evaluation Unit

A 2-year, $652,333 grant from the National Institute of Allergy and Infectious Diseases. Major goals: The major goal of this project is for Seattle Children’s lab to perform laboratory work in support of the Division of Microbiology and Infectious Disease (DMID) clinical trial 20-0034. The Kaiser Permanente Washington Health Research Institute lead investigator is Lisa Jackson.

Multilevel Interventions to Increase Adherence to Lung Cancer Screening

A 5-year, $3,299,124 grant from the National Cancer Institute. Major goals: To test multilevel interventions to increase adherence to lung cancer screening, measured by receipt of on-time low-dose computed tomography, improvement in knowledge when due, and formative evaluation of implementation. The Kaiser Permanente Washington Health Research Institute lead investigator is Karen Wernli.

Natural Language Programming Infrastructure: Word Embeddings

A 1-year, $17,926 grant from the Kaiser Permanente Washington Health Research Institute Small Grants Program. Major goals: The goal of this project is to improve natural language programming models by creating high-quality word embeddings locally trained on Kaiser Permanente Washington clinic progress notes. The Kaiser Permanente Washington Health Research Institute lead investigator is David Cronkite.

A 1-year, $145,000 grant from the Commonwealth of Australia. Major goals: The major goal of this project is to estimate performance measures for digital breast tomosynthesis and digital mammography in women with a personal history of breast cancer. The knowledge gained will inform policy decisions on surveillance imaging. The Kaiser Permanente Washington Health Research Institute lead investigator is Ellen O'Meara.

Kaiser Foundation Health Plan of Washington — FareStart

A 2-year, $17,454 grant from Kaiser Foundation Health Plan of Washington Community Benefit. Major goals: The major goals of this project are to conduct a process and impact evaluation of the FareStart prepared-meals collaboration with Downtown Emergency Service Center and Plymouth Housing, to support evaluation capacity building at FareStart and to conduct a literature review addressing outcomes of similar programs. The Kaiser Permanente Washington Health Research Institute lead investigator is Amy Lee.

The Primary School Parent Coaching Evaluation

A 1-year, $45,000 grant from the Stupski Foundation. Major goals: The goals for the Primary School Parent Coaching evaluation are under development and emergent. Based on current priorities, we expect to address the following evaluation questions, which will be refined further through conversations:

1. What facilitators, challenges, and lessons learned can be captured regarding parent coaching?
2. What outcomes measured with what tools are of greatest interest to key stakeholders?
3. What program aspects can be replicated/scaled, and how do we make the case/tell the story best?
4. What would be needed to design a rigorous, publishable evaluation study that systematically measures outcomes of greatest interest to key stakeholders?

The Kaiser Permanente Washington Health Research Institute lead investigator is Elena Kuo.

Projects and Cores within:
P1 Movement: A 5-year, $3,542,204 grant. The KPWHRI lead investigator is Dori Rosenberg. (R220014001)
P2 Subtypes: A 5-year, $3,706,278 grant.  The KPWHRI lead investigator is Marlaine Gray. (R220014002)
P3 Pharma: A 5-year, $3,696,569 grant. The KPWHRI lead investigator is Jennifer Nelson. (R220014003)
CA Admin: A 5-year, $6,444,766 grant. The KPWHRI lead investigator is KatieRose Richmire. (R220014004)​​​​​​​
CB Clinical: A 5-year, $15,968,503 grant. The KPWHRI lead investigator is Eric Larson. (R220014005)​​​​​​​
CC Lifecourse: A 5-year, $4,645,767 grant. The KPWHRI lead investigator is Laura Harrington. (R220014006)​​​​​​​
CD Neuropath: A 5-year, $5,743,456 grant. The KPWHRI lead investigator is Eric Larson. (R220014007)​​​​​​​
CE Neuroimaging: A 5-year, $3,482,484 grant. The KPWHRI lead investigator is Eric Larson. (R220014008)​​​​​​​
CF Data Analysis: A 5-year, $8,409,033 grant. The KPWHRI lead investigator is Jennifer Nelson. (R220014009)

Cancer Survivors and COVID-19

A 1-year, $19,916 grant from the Kaiser Permanente Washington Health Research Institute Small Grants Program. Major goals: Given the severity of COVID-19 in those with underlying conditions and the deleterious financial and social impact of the COVID-19 pandemic, we hypothesize that cancer survivors will be disproportionately impacted by the physical, mental, and social health consequences of COVID-19. To characterize the impact of COVID-19 on cancer survivors and identify populations of cancer survivors that are at highest risk for the impacts of the COVID-19 pandemic, we will: 1) Compare the rates of COVID-19 illness, hospitalization, and death between patients with a history of cancer and those with no prior history of cancer, and 2) Among those with a history of cancer, evaluate the association between age, sex, race/ethnicity, region, household characteristics, smoking history, comorbidity status, body mass index (BMI), cancer type, treatment, and time since cancer diagnosis and risk of COVID-19 illness, hospitalization, and death. The Kaiser Permanente Washington Health Research Institute lead investigator is Aruna Kamineni. (R221049001)

Design and Testing of a mHealth App for Ambivalent Smokers Living with Human Immunodeficiency Virus (HIV): A Randomized Pilot Study

A 1-year, $451,000 grant from the National Cancer Institute. Major goals: To conduct initial design and development of an mHealth app targeted to smokers living with HIV who are ambivalent about quitting and to conduct preliminary feasibility and acceptability testing. The Kaiser Permanente Washington Health Research Institute lead investigator is Jennifer McClure. (R220103001)

Development of Cerebrovascular Disease and Dementia in Women with History of Preeclampsia

A 2-year, $323,694 grant from the National Institute on Aging. Major goals: The major goals of this project are to augment existing reproductive phenotypic data in the Adult Changes in Thought (ACT) study with detailed obstetric phenotyping and to explore the association between preeclampsia and other pregnancy outcomes in relation to the development of Alzheimer’s disease and its related dementias. The Kaiser Permanente Washington Health Research Institute lead investigator is Laura Harrington. (R219134001)

Real World Endpoints (RWE): Coagulopathy Implementation Study

A 1-year, $75,778 grant from the Food and Drug Administration. Major goals: The major goal of this study is to understand the natural history of coagulopathy among COVID-19 patients. Our current efforts focus on development of a study synopsis with study specific aims, as well as partnership with select Sentinel Network Data Partners to generate feasibility data. The Kaiser Permanente Washington Health Research Institute lead investigator is Laura Harrington. (R219078017)

The Kaiser Permanente Washington Health Research Institute lead investigator is Elena Kuo.

Clinical Care Gaps and Unmet Needs in Adolescent and Young Adult (AYA) Cancers (Cores A & B)

A 5-year, $2,046,914 grant from the National Cancer Institute. Major goals: This program of research focuses on cancer care and outcomes for people diagnosed with cancer during the adolescent and young adult (AYA) age range, from 15 to 39 years old. Project 1 focuses on fertility concerns and use of reproductive health services and their impact on cancer treatment. Project 2 focuses on care transitions from active cancer treatment to surveillance and ancillary services in the period 2 to 5 years after diagnosis. Project 3 documents medical conditions and late effects that occur in AYA cancer survivors and identifies factors that influence likelihood of developing these conditions. These projects are supported by 3 cores: an administrative core, a biostatistics and data harmonization shared resource, and a survey shared resource. The Kaiser Permanente Washington Health Research Institute lead investigator is Jessica Chubak.

GlaxoSmithKline Pregnancy Exposure Study (Phase I)

A 2-year, $302,486 grant from GlaxoSmithKline. Major goals: The objectives of the study are to characterize the use of certain new medications during pregnancy specifically and more generally among women of childbearing years (ages 10 to 54 years). The study will also describe women of childbearing years and pregnant women with systemic lupus erythematosus (SLE) who are unexposed to the medications of interest during pregnancy. The Kaiser Permanente Washington Health Research Institute lead investigator is Sascha Dublin.

Maintenance of the Innovation Center (Year 2)

A 1-year, $47,640 grant from the Food and Drug Administration. Major goals: The major goals of this project are to establish and to create the organizational structure, administrative processes, and governance for the Innovation Center (IC) and its network of scientific collaborators. The IC shall build and maintain a diverse team with expertise in epidemiology, clinical medicine, pharmacy, statistics, health informatics, data science (specifically, artificial intelligence [natural language processing, machine learning]), network operations, and training to achieve the goals of this requirement, and shall be capable of initiating up to 7 new projects. The Kaiser Permanente Washington Health Research Institute lead investigator is Jennifer Nelson.

SARS-CoV-2 Serology and Vaccination Response

A 1-year, $66,048 grant from the Garfield Memorial Fund. Major goals: The major goals of the project are to evaluate antibody responses following SARS-CoV-2 vaccination and to estimate risks of "long COVID" and whether there are serologic markers after initial infection that predict long COVID risk. The Kaiser Permanente Washington Health Research Institute lead investigator is Michael L. Jackson.

A 1-year, $10,241 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Note: This qualitative study was completed in 2018. It has ongoing IRB approval and was reviewed and approved by Tanya Matthews. We interviewed 15 KPWA women who had reported using cannabis during pregnancy about their reasons for use. We audio-recorded and transcribed the interviews and created a coding memo by the end of the study. Major goals: The goal of this project is to continue manuscript writing, with Linda Kiel as lead author (original project PM and coder) and Clarissa Hsu (co-investigator, interviewer and co-author), and to submit the manuscript, with acceptance by the end of the year. The KPWHRI lead investigator is Gwen Lapham.

Elevating Consumer Voice in Phase 2 of the Delta Center for a Thriving Safety Net Initiative

A 3-year, $450,592 grant from the Robert Wood Johnson Foundation. Major goals: The major goals of this project are to build capacity of state primary care and behavioral health associations to support value-based pay and care in 20 states, to explore how to elevate consumer voice in policy and practice improvements, and to share learnings with the field. The Kaiser Permanente Washington Health Research Institute lead investigator is Katie Coleman.

I See You — Improved Social and Economic Outcomes (ISEO): Elevating Diverse Stakeholder Perspectives in this Rural Landscape Strategy Assessment

A 2-year, $499,253 grant from the Robert Wood Johnson Foundation. Major goals: The strategy assessment will articulate the overarching theory of change for this body of work; examine the strategic decisions made in developing, funding, and managing this body of work; gauge the progress made toward the intended outcomes; and provide consultations for the role that the Robert Wood Johnson Foundation could play in advancing opportunity, health, and equity in rural communities moving forward. The Kaiser Permanente Washington Health Research Institute lead investigator is Emily Bourcier.

Kaiser Permanente Washington Health Research Institute Mental Health Advocate Group

A 1-year, $6,330 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Major goals: The major goals of this project are to develop and sustain the mental health advocacy group, to establish infrastructure allowing Kaiser Permanente Washington employees with lived experience of mental health problems to provide strategic consultation for behavioral health research, and to destigmatize mental illness at KPWHRI and foster a culture of empathy and transparency. The KPWHRI lead investigator is Janna Webbon.

Medication Orders Data Investigation

A 1-year, $16,118 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Major goals: The major goal of this project is to better understand and document linkage of pharmacy records between medications that are ordered versus those that get dispensed. The KPWHRI lead investigator is Dustin Key.

Mom Baby Link Infrastructure Update

A 1-year, $12,099 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Major goals: The goal of this project is to update the Mother-Baby linkage file to include data through 2020 and to disseminate information about the updated dataset within KPWHRI. The KPWHRI lead investigator is Sharon Fuller.

MyPath: A Patient-Centered Web-Based Intervention to Improve Reproductive Planning for Women Veterans

A 4-year, $55,674 grant from VA Health Services Research & Development. Major goals: The goal of MyPath is to test a novel patient-facing decision-support tool for reproductive care decisions and determine its impact on communication self-efficacy, knowledge, decisional conflict, and satisfaction with care. The Kaiser Permanente Washington Health Research Institute lead investigator is David Arterburn.

Paws Unite: Prototyping a Social Connection Innovation

A 1-year, $7,620 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Major goals: The major goals of this project are to collect preliminary data on the feasibility of an intervention to address loneliness that will be designed around the idea of visiting socially isolated neighbors on walks with our dogs, to conduct an environmental scan by posting queries on the idea to social media sites, and to conduct semi-structured interviews with community-based stakeholders and Kaiser Permanente Washington member advisors. The KPWHRI lead investigator is Leah Tuzzio.

Practical Awareness-Based Strategies for Eating

A 1-year, $50,048 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Major goals: We propose a 6-month randomized trial involving 20 Kaiser Permanente Washington (KPWA) patients with BMI =>25 kg/m2 (overweight or obesity). These patients will be assigned randomly to 1 of 2 approaches to Eat Right Now (a mindfulness based smartphone app) for weight loss: Approach 1: Eat Right Now Only (the Eat Right Now intervention plus educational materials, weekly physical activity goals, and a wi-fi-enabled digital body weight scale); Approach 2: Eat Right Now PLUS Coaching (everything in Approach 1, plus 24-weeks of asynchronous coaching by trained KPWA facilitators of the Eat Right Now intervention). The KPWHRI lead investigator is David Arterburn.

Research Data Warehouse Communication Strategy

A 1-year, $31,200 grant from the Kaiser Permanente Washington Health Research Institute (KPWHRI) Small Grants Program. Major goals: The goal of this project is to develop and implement a communication strategy for the research data warehouse. The KPWHRI lead investigator is Yonah Karp.

A 1-year, $542,609 grant from Kaiser Program Office Community Benefit. Major goals: The SONNET initiative is an inter-regional network of researchers and evaluators interested in understanding the role that social determinants of health play in the health of our members and in assessing the effectiveness of interventions to address social determinants. The Kaiser Permanente Washington Health Research Institute lead investigator is Katie Coleman.

Comparative Modeling of Precision Breast Cancer Control Across the Translational Continuum

A 5-year, $253,811 grant from the National Cancer Institute. Major goals: To evaluate the benefits and harms of precision screening strategies for breast cancer based on breast density and 5-year absolute risk of breast cancer, and to determine the best screening strategy in women with type 2 diabetes. The Kaiser Permanente Washington Health Research Institute lead investigator is Ellen O'Meara.

COVID-19 Data Resource Implementation: Sentinel Common Data Model v7.1.0 and Rapid COVID-19 Sentinel Distributed Database

A 1-year, $66,300 grant from the Food and Drug Administration (FDA). Major goals: The major goals of a Rapid COVID-19 Sentinel Distributed Database project are to use the FDA’s Sentinel Common Data Model (SCDM) v7.X.X nomenclature to avoid complication with the ongoing implementation of SCDM v8.0.0. For the duration of the project, participating data partners (DPs) will maintain two separate databases: one production-level curated and quality-checked database used for routine querying, and the Rapid COVID-19 Sentinel Distributed Database, which has an abbreviated quality assurance and quality control process. The Kaiser Permanente Washington Health Research Institute lead investigator is Denise Boudreau.

Enhancing Causal Inference in the Sentinel System

A 1-year, $44,480 grant from the Food and Drug Administration (FDA). Major goals: The major goals of this project are to focus on comparing the performance of targeted learning methods with causal inference approaches currently available to the FDA’s Sentinel System in data environments that include linked insurance claims and electronic health record (EHR) data. The proposal will further assess practical aspects of the feasibility of how such approaches might be implemented in a distributed environment. The Kaiser Permanente Washington Health Research Institute lead investigator is Jennifer Nelson.

Sentinel: Horizon Scan of Electronic Health Record Databases

A 1-year, $15,561 grant from the Food and Drug Administration (FDA). Major goals: This project will enhance the FDA’s Sentinel medical products safety surveillance methods. Existing surveillance methods depend heavily on structured claims data, but these data often lack precision for capturing exposures, important covariates, and outcomes. Information derived from clinical notes via natural language processing (NLP) and other unstructured data such as laboratory findings will be used to investigate medical products safety with greater precision — through the lens of the clinician rather than the insurer. The Kaiser Permanente Washington Health Research Institute lead investigator is David Carrell.

Sentinel Year 7 (Operational Year 2021) Infrastructure

A 1-year, $99,744 grant from the Food and Drug Administration (FDA). Major goals: The major goals of this project are to continue the work required for the FDA’s Sentinel data partners (DPs) under the operational year 2021 Infrastructure work order. Most of the requirements involve DP staff to run data requests or return data and documents of various types to the Sentinel Operations Center via the Sentinel PopMedNet Distributed Query Tool System. The Kaiser Permanente Washington Health Research Institute lead investigator is Denise Boudreau.

Sentinel Year 7 (Operational Year 2021) Querying

A 1-year, $51,165 grant from the Food and Drug Administration (FDA). Major goals: The major goals of this project are to support the routine querying tasks required for the FDA’s Sentinel data partners (DPs) in operational year 2021. Routine querying involves execution of standard modular programs, sometimes supplemented with minimal amounts of custom coding (developed by the Sentinel Operations Center), against a DP’s production Sentinel Distributed Database — that is, last approved refresh or ETL (extract, transform, load). DPs will receive query requests and be asked to “opt in” by executing the routine query and transmitting aggregated results back to the Sentinel Operations Center. The Kaiser Permanente Washington Health Research Institute lead investigator is Denise Boudreau.

A 5-year, $324,996 grant from the NCI. Major goals: To develop the NCI National Community Oncology Research Program. The Kaiser Permanente Washington Health Research Institute lead investigator is Karen Wernli.

Moderna's External Safety Advisory Board (ESAB) for mRNA-1273

A 1-year, $27,857 grant from ModernaTX, Inc. Major goals: The major aims of this project are to provide statistical expertise in vaccine safety as part of Moderna's External Safety Advisory Board (ESAB) for mRNA-1273 (their candidate COVID-19 vaccine), as Moderna prepares to receive an Emergency Use Authorization from the Food and Drug Administration (FDA).  The Kaiser Permanente Washington Health Research Institute lead investigator is Jennifer Nelson.

Vaccine Safety Datalink Project (VSD) COVID Participation- Request for Task Order Proposal

A 3-year, $280,310 grant from the Centers for Disease Control and Prevention. Major goals: The purpose of this task order is for the contractors to contribute to the main functions of VSD COVID-19 vaccine safety activities. The work from this task order will support and contribute to the COVID-19 vaccine safety work of the VSD. The Kaiser Permanente Washington Health Research Institute lead investigator is Lisa Jackson.