Cardiovascular Health
“One in four deaths in the United States is attributed to heart disease. Our researchers study how behavior, environment, and genetics affect heart health and how screening and treatment can reduce risk.”
Research overview
Heart disease is the leading cause of death for Americans. Kaiser Permanente Washington Health Research Institute (KPWHRI) scientists are working to understand how to reduce our risk of heart attacks, stroke, and other cardiovascular diseases throughout life.
Addressing risk factors, improving diagnosis, and exploring how medications, genes, and everyday life affect our cardiovascular health at different ages and stages are central to this work — as is translating research findings into practical, personalized care.
“We’ve found that helping patients and health care teams work together on personalized care plans is the best path to lifelong heart health,” says Beverly Green, MD, MPH, whose recent work has focused on improving the diagnosis of high blood pressure.
Additional focus areas for KPWHRI scientists include exploring the impact of cardiovascular diseases on other health conditions — and vice versa. Recently, this has led researchers Sascha Dublin, MD, PhD, and Laura B. Harrington, PhD, MPH, to investigate the impact of COVID-19 on cardiovascular health.
Below are other research highlights from KPWHRI’s cardiovascular health scientists (please visit their bios to learn more):
- In 2016 Dr. Green, a senior investigator, launched the BP-CHECK study, which aims to find the easiest, most accurate way to diagnose high blood pressure. With a $2.8 million award from the Patient-Centered Outcomes Research Institute (PCORI), the study compares blood pressure readings taken in clinic, at home, and at validated blood pressure kiosks to the 24-hour blood pressure test that is currently considered the gold standard for diagnosing hypertension.
- Dr. Dublin, a senior investigator, explores many different facets of cardiovascular disease in her work, including risk factors for atrial fibrillation, the effect of medications on cardiovascular disease, and the relationship between cardiovascular disease and other conditions, such as dementia. Managing cardiovascular risk factors in pregnancy — such as high blood pressure and diabetes — is a particular interest.
- Dr. Harrington, an assistant investigator, is a cardiovascular epidemiologist whose research aims to improve understanding of modifiable cardiovascular risk factors, particularly among older women. Currently, she is leading a study exploring the relationship between physical activity, sedentary behavior, and the risk of venous thromboembolism (blood clots that form predominantly in the veins of the legs or lungs). In addition to this work, Dr. Harrington conducts research in the areas of recurrent cardiovascular event risk, cardiovascular health in relation to cognitive decline and dementia risk in later life, and pharmacologic exposures in relation to cardiovascular event risk, with a particular focus on risk factors for venous thromboembolism.
- Senior Investigator Michael L. Parchman, MD, MPH, focuses on implementing evidence-based cardiovascular disease care into primary care settings. He led the 4-year Healthy Hearts Northwest trial, an EvidenceNOW initiative that helped smaller primary care practices in Washington, Oregon, and Idaho adopt evidence-based approaches to improving cardiovascular care outcomes. The trial continues to produce findings of importance.
- The work of Ellen O'Meara, PhD, a senior research associate, centers on the epidemiology of common and important health conditions in the United States, including cardiovascular disease. Her collaborative research has included studies exploring the risk factors and outcomes of heart disease and stroke. Recent work includes research on quality improvement aimed at controlling hypertension at small primary care practices.
Recent publications on Cardiovascular Health
van der Lee SJ, Knol MJ, Chauhan G, Satizabal CL, Smith AV, Hofer E, Bis JC, Hibar DP, Hilal S, van den Akker EB, Arfanakis K, Bernard M, Yanek LR, Amin N, Crivello F, Cheung JW, Harris TB, Saba Y, Lopez OL, Li S, van der Grond J, Yu L, Paus T, Roshchupkin GV, Amouyel P, Jahanshad N, Taylor KD, Yang Q, Mathias RA, Boehringer S, Mazoyer B, Rice K, Cheng CY, Maillard P, van Heemst D, Wong TY, Niessen WJ, Beiser AS, Beekman M, Zhao W, Nyquist PA, Chen C, Launer LJ, Psaty BM, Ikram MK, Vernooij MW, Schmidt H, Pausova Z, Becker DM, De Jager PL, Thompson PM, van Duijn CM, Bennett DA, Slagboom PE, Schmidt R, Longstreth WT, Ikram MA, Seshadri S, Debette S, Gudnason V, Adams HHH, DeCarli C. A genome-wide association study identifies genetic loci associated with specific lobar brain volumes. Commun Biol. 2019 Aug 2;2(1):285. doi: 10.1038/s42003-019-0537-9. PubMed
Dashti HS, Merino J, Lane JM, Song Y, Smith CE, Tanaka T, McKeown NM, Tucker C, Sun D, Bartz TM, Li-Gao R, Nisa H, Reutrakul S, Lemaitre RN, Alshehri TM, de Mutsert R, Bazzano L, Qi L, Knutson KL, Psaty BM, Mook-Kanamori DO, Perica VB, Neuhouser ML, Scheer FAJL, Rutter MK, Garaulet M, Saxena R Genome-wide association study of breakfast skipping links clock regulation with food timing 2019 Aug;110(2):473-484. doi: 10.1093/ajcn/nqz076. PubMed
Merino J, Guasch-Ferré M, Ellervik C, Dashti HS, Sharp SJ, Wu P, Overvad K, Sarnowski C, Kuokkanen M, Lemaitre RN, Justice AE, Ericson U, Braun KVE, Mahendran Y, Frazier-Wood AC, Sun D, Chu AY, Tanaka T, Luan J, Hong J, Tjønneland A, Ding M, Lundqvist A, Mukamal K, Rohde R, Schulz CA, Franco OH, Grarup N, Chen YI, Bazzano L, Franks PW, Buring JE, Langenberg C, Liu CT, Hansen T, Jensen MK, Sääksjärvi K, Psaty BM, Young KL, Hindy G, Sandholt CH, Ridker PM, Ordovas JM, Meigs JB, Pedersen O, Kraft P, Perola M, North KE, Orho-Melander M, Voortman T, Toft U, Rotter JI, Qi L, Forouhi NG, Mozaffarian D, Sørensen TIA, Stampfer MJ, Männistö S, Selvin E, Imamura F, Salomaa V, Hu FB, Wareham NJ, Dupuis J, Smith CE, Kilpeläinen TO, Chasman DI, Florez JC. Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis. BMJ. 2019;366:l4292. doi: 10.1136/bmj.l4292. PubMed
Glessner JT, Li J, Desai A, Palmer M, Kim D, Lucas AM, Chang X, Connolly JJ, Almoguera B, Harley JB, Jarvik GP, Ritchie MD, Sleiman PMA, Roden DM, Crosslin D, Hakonarson H. CNV association of diverse clinical phenotypes from eMERGE reveals novel disease biology underlying cardiovascular disease. Int J Cardiol. 2019 Jul 19. pii: S0167-5273(19)30191-3. doi: 10.1016/j.ijcard.2019.07.058. [Epub ahead of print]. PubMed
Cheadle A, Rosaschi M, Burden D, Ferguson M, Greaves B, Houston L, McClendon J, Minkoff J, Jones M, Schwartz P, Nudelman J, Maddux-Gonzalez M A Community-Wide Collaboration to Reduce Cardiovascular Disease Risk: The Hearts of Sonoma County Initiative 2019 Jul 11;16:E89. doi: 10.5888/pcd16.180596. Epub 2019-07-11. PubMed
Researchers in Cardiovascular Health
 Meagan C. Brown, PhD, MPHAssistant Investigator |
 Sascha Dublin, MD, PhDSenior Investigator |
 Nicole M. Gatto, PhD, MPHPrincipal Collaborative Scientist |
 Beverly B. Green, MD, MPHSenior Investigator |
 Laura Harrington, PhD, MPHAssociate Investigator |
Affiliate researchers
James Floyd, MD, MS
Assistant Professor, Department of Medicine
Adjunct Assistant Professor, Department of Epidemiology
University of Washington
Susan Heckbert, MD, PhD
University of Washington (UW) Department of Epidemiology; UW Cardiovascular Health Research Unit
Nicholas L. Smith, PhD, MPH
UW Professor, Epidemiology, Cardiovascular Health Research Unit
Director, Seattle Epidemiology and Information Resource Center, VA Puget Sound Health Care System
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Taking more breaks from sitting could potentially lower the risk.
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Study finds bariatric surgery linked to substantially lower risk of blood clots long-term
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Live healthy
Measuring blood pressure at home: It's easy and accurate
Bev Green, doctor and scientist, has tips for monitoring your blood pressure without leaving your house.
Healthy findings blog
New grant boosts research on cardiovascular disease
Epidemiologist Laura B. Harrington, PhD, MPH, speaks about working in cardiovascular and aging research.
Research to practice
Home blood pressure monitoring: From study to clinic
Beverly Green, MD, and Kaiser Permanente work to improve hypertension care.
Research
Is blood pressure reading better at home or clinic?
Home blood pressure monitoring shown to be an excellent alternative for making new diagnoses of hypertension.
New findings
There’s no place like home … to track blood pressure
Research led by KPWHRI’s Beverly Green, MD, MPH, finds that patients prefer at-home monitoring of blood pressure.
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