Research on health informatics at Kaiser Permanente Washington focuses on developing and using health information technology (IT) to transform health care delivery. By testing new paradigms of care that provide more opportunities to engage patients, this research is supplying valuable evidence that is helping shape federal policy and guiding innovative redesign of health care.
“We’re working to understand how to make health IT practical so patients and care teams find it useful and engaging,” explained Kaiser Permanente Washington Health Research Institute (KPWHRI) Senior Investigator James Ralston, MD, MPH. “We want to find ways to use information technologies to support patients and providers together, both inside and outside the office.”
Integral to this support is designing technologies that are user-friendly and meet the needs of both patients and providers. By applying human-centered methods that focus on needs, use, and usability, KPWHRI researchers inform the design of health IT with direct participation from users.
Groundbreaking methodological work by KPWHRI health informatics researchers includes developing natural language processing (NLP) to analyze text such as notes and written reports in electronic health records (EHRs). Assistant Investigator David Carrell, PhD, leads in the area of using NLP and machine learning to identify patient phenotypes, or specific health characteristics such as possible heart disease, risk of opioid overdose, or suggestion of colon cancer. This information can assist researchers in studying how genetics and other factors influence disease.
Other examples of KPWHRI health informatics research include projects using EHRs and secure electronic communications such as:
Examples of KPWHRI research in mobile health (mHealth) and user-centered design include:
“Our studies on using health IT to improve care are showing that we can achieve better outcomes when we shift care from the doctor’s office to where people live: in their homes—and online,” said Senior Investigator Beverly B. Green, MD, MPH.
Hubbard RA, Lett E, Ho GYF, Chubak J. Characterizing bias due to differential exposure ascertainment in electronic health record data. Health Serv Outcomes Res Methodol. 2021;21(3):309-323. doi: 10.1007/s10742-020-00235-3. Epub 2021 Jan 4. PubMed
Wyner Z, Dublin S, Chambers C, Deval S, Herzig-Marx C, Rao S, Rauch A, Reynolds J, Brown JS, Martin D. The FDA MyStudies app: a reusable platform for distributed clinical trials and real-world evidence studies. JAMIA Open. 2020 Dec 11;3(4):500-505. doi: 10.1093/jamiaopen/ooaa061. eCollection 2020 Dec. PubMed
Grant RW, McCloskey J, Hatfield M, Uratsu C, Ralston JD, Bayliss E, Kennedy CJ. Use of latent class analysis and k-Means clustering complex patient profiles. JAMA Netw Open. 2020 Dec 1;3(12):e2029068. doi: 10.1001/jamanetworkopen.2020.29068. PubMed
Kharbanda EO, Vazquez-Benitez G, DeSilva MB, Spaulding AB, Daley MF, Naleway AL, Irving SA, Klein NP, Tseng HF, Jackson LA, Hambidge SJ, Olaiya O, Panozzo CA, Myers TR, Romitti PA. Developing algorithms for identifying major structural birth defects using automated electronic health data. Pharmacoepidemiol Drug Saf. 2020 Nov 20. doi: 10.1002/pds.5177. Online ahead of print. PubMed
Landes SJ, Kerns SEU, Pilar MR, Walsh-Bailey C, Yu SH, Byeon YV, Crane ME, Larson M, Bullock HL, Baumann AA, Comtois KA, Darnell D, Dorsey S, Fizur P, Lewis CC, Moullin JC, Pierson A, Powell BJ, Stanick CF, Wiltsey Stirman S, Franks RP. Where the rubber meets the road: the intersection of research, policy, and practice - part 2. Implement Sci. 15, 80 (2020). https://doi.org/10.1186/s13012-020-01033-8. PubMed
James D. Ralston, MD, MPHSenior Investigator |
Jennifer B. McClure, PhDDirector, Investigative Science |
Beverly B. Green, MD, MPHSenior Investigator |
Katharine A. Bradley, MD, MPHSenior Investigator |
Paula Lozano, MD, MPHSenior Investigator; Director, ACT Center |
Yates Coley, PhDAssociate Biostatistics Investigator |
Brian D. Williamson, PhDAssistant Biostatistics Investigator |
Annie Hoopes, MD, MPHActing Assistant Investigator |
Claire Allen, MPHManager, Collaborative Science |
Annie Piccorelli, PhDSenior Collaborative Biostatistician |