Research on health informatics at Kaiser Permanente Washington focuses on developing and using health information technology (IT) to transform health care delivery. By testing new paradigms of care that provide more opportunities to engage patients, this research is supplying valuable evidence that is helping shape federal policy and guiding innovative redesign of health care.
“We’re working to understand how to make health IT practical so patients and care teams find it useful and engaging,” explained Kaiser Permanente Washington Health Research Institute (KPWHRI) Senior Investigator James Ralston, MD, MPH. “We want to find ways to use information technologies to support patients and providers together, both inside and outside the office.”
Integral to this support is designing technologies that are user-friendly and meet the needs of both patients and providers. By applying human-centered methods that focus on needs, use, and usability, KPWHRI researchers inform the design of health IT with direct participation from users.
Groundbreaking methodological work by KPWHRI health informatics researchers includes developing natural language processing (NLP) to analyze text such as notes and written reports in electronic health records (EHRs). Assistant Investigator David Carrell, PhD, leads in the area of using NLP and machine learning to identify patient phenotypes, or specific health characteristics such as possible heart disease, risk of opioid overdose, or suggestion of colon cancer. This information can assist researchers in studying how genetics and other factors influence disease.
Other examples of KPWHRI health informatics research include projects using EHRs and secure electronic communications such as:
Examples of KPWHRI research in mobile health (mHealth) and user-centered design include:
“Our studies on using health IT to improve care are showing that we can achieve better outcomes when we shift care from the doctor’s office to where people live: in their homes—and online,” said Senior Investigator Beverly B. Green, MD, MPH.
Burnett-Hartman AN, Kamineni A, Corley DA, Singal AG, Halm EA, Rutter CM, Chubak J, Lee JK, Doubeni CA, Inadomi JM, Doria-Rose VP, Zheng Y. Colonoscopy indication algorithm performance across diverse health care systems in the PROSPR consortium. eGEMS (Wash DC). 2019;7(1):37. doi: 10.5334/egems.296. PubMed
King KM, Pullmann MD, Lyon AR, Dorsey S, Lewis CC. Using implementation science to close the gap between the optimal and typical practice of quantitative methods in clinical science. J Abnorm Psychol. 2019;128(6):547-562. doi: 10.1037/abn0000417. PubMed
Anthony MS, Armstrong MA, Getahun D, Scholes D, Gatz J, Schulze-Rath R, Postlethwaite D, Merchant M, Alabaster AL, Chillemi G, Raine-Bennett T, Xie F, Chiu VY, Im TM, Takhar HS, Fassett M, Grafton J, Cronkite D, Ichikawa L, Reed SD, Hui SL, Ritchey ME, Saltus CW, Andrews EB, Rothman KJ, Asiimwe A, Lynen R, Schoendorf J. Identification and validation of uterine perforation, intrauterine device expulsion, and breastfeeding in four health care systems with electronic health records. Clin Epidemiol. 2019 Jul 23;11:635-643. doi: 10.2147/CLEP.S201044. eCollection 2019. PubMed
Hripcsak G, Shang N, Peissig PL, Rasmussen LV, Liu C, Benoit B, Carroll RJ, Carrell DS, Denny JC, Dikilitas O, Gainer VS, Marie Howell K, Klann JG, Kullo IJ, Lingren T, Mentch FD, Murphy SN, Natarajan K, Pacheco JA, Wei WQ, Wiley K, Weng C. Facilitating phenotype transfer using a common data model. J Biomed Inform. 2019 Jul 17:103253. doi: 10.1016/j.jbi.2019.103253. [Epub ahead of print]. PubMed
Namjou B, Lingren T, Huang Y, Parameswaran S, Cobb BL, Stanaway IB, Connolly JJ, Mentch FD, Benoit B, Niu X, Wei WQ, Carroll RJ, Pacheco JA, Harley ITW, Divanovic S, Carrell DS, Larson EB, Carey DJ, Verma S, Ritchie MD, Gharavi AG, Murphy S, Williams MS, Crosslin DR, Jarvik GP, Kullo IJ, Hakonarson H, Li R; eMERGE Network, Xanthakos SA, Harley JB. GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network. BMC Med. 2019 Jul 17;17(1):135. doi: 10.1186/s12916-019-1364-z. PubMed
James D. Ralston, MD, MPHSenior Investigator |
Jennifer B. McClure, PhDDirector, Investigative Science |
Beverly B. Green, MD, MPHSenior Investigator |
Katharine A. Bradley, MD, MPHSenior Investigator |
Paula Lozano, MD, MPHSenior Investigator; Director, ACT Center |
Yates Coley, PhDAssociate Biostatistics Investigator |
Brian D. Williamson, PhDAssistant Biostatistics Investigator |
Annie Hoopes, MD, MPHActing Assistant Investigator |
Claire Allen, MPHManager, Collaborative Science |
Annie Piccorelli, PhDSenior Collaborative Biostatistician |