Karen J. Wernli, PhD

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“I consider patients the core of my research.”

Karen J. Wernli, PhD

Senior Scientific Investigator, Kaiser Permanente Washington Health Research Institute
Professor, Department of Health System Science, Kaiser Permanente Bernard J. Tyson School of Medicine
Affiliate Professor, Department of Epidemiology and Department of Health Systems and Population Health, University of Washington

Karen.J.Wernli@kp.org
206-287-2934
Twitter: @wernlikarenj

Biography

Karen Wernli, PhD, is a cancer epidemiologist and health services researcher whose work focuses on incorporating patient-centered outcomes to improve cancer care along the cancer care continuum, from prevention to survivorship. Her works spans several types of cancer, including lung, breast, and colorectal, and also explores the impact of cancer in special populations, such as adolescents and young adults. Her research strives to answer critical questions at the confluence of patients’ needs and clinical priorities. Overall, her research has resulted in approximately $30 million in research funding as principal investigator (PI) or site PI, more than 125 peer-reviewed publications (h-index 35), and more than 85 presentations at national conferences, symposia, and other public venues.

Dr. Wernli is a leader in multilevel intervention studies to improve lung cancer screening. She is currently conducting a pragmatic clinical trial funded by the National Cancer Institute (NCI) to test 2 multilevel interventions to improve adherence to annual lung cancer screening at Kaiser Permanente Washington (R01CA262015). Study interventions were developed using a mixed-methods approach — including patient and stakeholder engagement and human-centered design methods — to determine gaps for interventions, relevant features of interventions, and design concepts. Further, Dr. Wernli is also leading a pilot grant from the Alliance for Clinical Trials in Oncology to develop interventions to improve timely follow-up after a positive lung cancer screening scan. She is cancer care delivery research lead for the Kaiser Permanente Washington NCI Community Oncology Research Program (NCORP).

Dr. Wernli is a leader in the use of breast imaging in women with prior breast cancer, including in the use of breast magnetic resonance imaging (MRI). Dr. Wernli recently completed a Patient-Centered Outcomes Research Institute (PCORI) project that compared breast MRI to mammography for women already treated for breast cancer. Called Surveillance Imaging Modalities for Breast Cancer Assessment (SIMBA), the study used data from the Breast Cancer Surveillance Consortium (BCSC) and engaged patients and stakeholders to determine the best information for patient and physician decision-making. Dr. Wernli’s team translated that information into a new decision aid for breast cancer survivors. PCORI has recognized this work nationally and pointed to SIMBA as a model for effective patient engagement.

Dr. Wernli’s other breast cancer projects include collaborating with Natasha Stout, PhD, from Harvard University on an NCI-funded study to examine trends and outcomes related to the mandatory notification of breast density that has been enacted in many states. She also led research to determine temporal trends in the use of breast MRI over 10 years, based on indication for the scans. The analysis relied on national claims-based data across all 50 states.

Dr. Wernli is leading patient-centered research in adolescent and young adult (AYA) populations. She is a project co-lead with Kaiser Permanente Southern California researcher Erin Hahn, PhD, MPH, and Veterans Affairs researcher Neetu Chawla, PhD, MPH, in an NCI-funded project to evaluate health service utilization in early survivorship for AYA populations. The research is intended to identify multilevel gaps in health care utilization in AYA early-cancer survivors for forthcoming interventions. Previously, Dr. Wernli launched the Clare Project with KPWHRI researchers, including Marlaine Figueroa Gray, PhD, to understand patient, caregiver, and provider perspectives regarding medical decision-making for patients with advanced cancer. Using novel methods, all perspectives were garnered through social media recruitment. With NCI-funding, she has evaluated temporal trends and regional variation in end-of-life care in AYA cancer populations using national claims-based data.

Finally, Dr. Wernli is expanding her research expertise in clinical research studies beyond oncology clinical trials. She is principal investigator of a multisite study of flu and COVID-19 vaccine effectiveness funded by the Centers for Disease Control and Prevention from 2022 to 2027. Her study team is annually enrolling about 1,200 participants with flu-like symptoms into her research.

Dr. Wernli is a member of the American Society for Preventive Oncology, the Society for Epidemiologic Research, the American Society for Clinical Oncology, and the American Association for Cancer Research. She is an affiliate professor of epidemiology and health systems and population health at the University of Washington and a professor of health system science at the Kaiser Permanente Bernard J. Tyson School of Medicine.

Research interests and experience

  • Cancer

    Breast, lung, colorectal, ovarian, skin, and endometrial cancer; screening and surveillance; survivorship; patient-centered care; biostatistics; low-dose CT (LDCT); mammography; surveillance imaging; breast magnetic resonance imaging (MRI); systematic reviews; multilevel intervention studies; pragmatic clinical trials

  • Health Services & Economics

    Comparative effectiveness research, health outcomes research, patient-centered outcomes, health care quality, implementation science

    Preventive Medicine

    Cancer screening and surveillance

  • Patient-Centeredness

    Patient engagement, stakeholder engagement, qualitative research methods, mixed-methods, human-centered design

  • Vaccines & Infectious Diseases

  • Aging & Geriatrics

Recent publications

Kerlikowske K, Zhu WW, Hubbard R, Gellar B, Dittus K, Braithwaite D, O’Meara E, Wernli KJ, Miglioretti D, for the Breast Cancer Surveillance Consortium. Outcomes of screening mammography by frequency, breast density and postmenopausal hormone therapy. JAMA Intern Med. 2013 May 13;173(9):807-16. doi:10.1001/jamainternmed.2013.307. Epub 2013 Mar 18. PubMed

Wernli KJ, Inadomi JM. Anesthesia for colonoscopy: too much of a good thing? Comment on "Complications following colonoscopy with anesthesia assistance." JAMA Intern Med. 2013 Apr 8;173(7):556-8. doi: 10.1001/jamainternmed.2013.4071. Epub 2013 Mar 11. PubMed

Braithwaite D, Zhu W, Hubbard RA, O'Meara ES, Miglioretti DL, Geller B, Dittus K, Moore D, Wernli KJ, Mandelblatt J, Kerlikowske K, for the Breast Cancer Surveillance Consortium. Screening outcomes in older U.S. women undergoing multiple mammograms in community practice: does interval, age or comorbidity score affect tumor characteristics or false positive rates? J Natl Cancer Inst. 2013 Mar 6;105(5):334-41. doi: 10.1093/jnci/djs645. Epub 2013 Feb 5. PubMed

Passarelli MN, Phipps AI, Potter JD, Makar KW, Coghill AE, Wernli KJ, White E, Chan AT, Hutter CM, Peters U, Newcomb PA. Common single nucleotide polymorphisms in the estrogen receptor beta promoter are associated with colorectal cancer survival in postmenopausal women.  Cancer Res. 2013 Jan 15;73(2):767-75. doi: 10.1158/0008-5472.CAN-12-2484. Epub 2012 Nov 13. PubMed

Carlos RC, Buist DS, Wernli KJ, Swan JS. Patient-centered outcomes in imaging: quantifying value.  J Am Coll Radiol. 2012;9(10):725-8. doi: 10.1016/j.jacr.2012.06.008. PubMed

Braithwaite D, Zhu W, Hubbard R, O'Meara ES, Miglioretti DL, Geller B, Dittus K, Wernli K, Moore D, Kerlikowske K, for the Breast Cancer Surveillance Consortium. Benefits and harms of screening mammography frequency by age and comorbidity score.  Cancer Epidemiol Biomarkers Prev. 2012;21(3):565. Epub 2012 Feb 15. PubMed

Schur EA, Elmore JG, Onega T, Wernli KJ, Sickles E, Haneuse S. The impact of obesity on follow-up after an abnormal screening mammogram.  Cancer Epidemiol Biomarkers Prev. 2012 Feb;21(2):327-36. Epub 2011 Dec 5. PubMed

Checkoway H, Ray RM, Lundin JI, Astrakianakis G, Seixas NS, Camp JE, Wernli KJ, Fitzgibbons ED, Li W, Feng Z, Gao DL, Thomas DB. Lung cancer and occupational exposures other than cotton dust and endotoxin among women textile workers in Shanghai, China. Occup Environ Med. 2011 Jun;68(6):425-9. doi: 10.1136/oem.2010.059519. Epub 2010 Dec 3. PubMed

Burnett-Hartman AN, Newcomb PA, Mandelson MT, Adams SV, Wernli KJ, Shadman M, Wurscher MA, Makar KW. Colorectal polyp type and the association with charred meat consumption, smoking, and microsomal epoxide hydrolase polymorphisms.  Nutr Cancer. 2011;63(4):583-92. PubMed

Coghill AE, Newcomb PA, Chia VM, Zheng Y, Wernli KJ, Passarelli MN, Potter JD. Pre-diagnostic NSAID use but not hormone therapy is associated with improved colorectal cancer survival in women.  Br J Cancer. 2011 Mar 1;104(5):763-8. Epub 2011 Feb 8. PubMed

 

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